UNC119 and GSTM4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UNC119	GSTM4
Description		unc-119 lipid binding chaperone	glutathione S-transferase mu 4
Image
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Intercellular Bridge Synapse Spindle Midzone	Cytoplasm Cytosol
	Molecular Function	Protein Binding Lipid Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Protein Binding Transferase Activity Lyase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Protein Transport Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Lipid Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process
Pathways			Glutathione conjugation Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Drugs			Glutathione Glutathione sulfonic acid S-octylglutathione Glutathione disulfide gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine Deoxycholic acid 1-Hydroxy-2-S-glutathionyl-3-para-nitrophenoxy-propane S-Hexylglutathione
Diseases
GWAS			Alcohol dependence ( 33290381) Seasonality and depression ( 30217971)
Interacting Genes		104 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CFTR CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24	10 interacting genes: APLP1 GSTM3 IGSF21 LRIF1 MED31 NELFCD TLE1 TP53 UNC119 ZBTB16
Entrez ID		9094	2948
HPRD ID		04927	00706
Ensembl ID		ENSG00000109103	ENSG00000168765
Uniprot IDs		K7EN86 Q13432	A0A140VKE3 A6NNT0 Q03013
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A 7UMO 9GKG	4GTU
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Glutamatergic Synapse Leukocyte Migration Positive Regulation Of Cell Activation Cytosol Enzyme Binding Positive Regulation Of Cell-cell Adhesion Protein Binding T Cell Receptor Binding RAGE Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Cell Development Regulation Of Calcium Ion Import Across Plasma Membrane Cytoplasm Nucleus T Cell Activation Positive Regulation Of Monoatomic Ion Transmembrane Transport Gamma-delta T Cell Receptor Complex Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Calcium-dependent Protein Binding Regulation Of T Cell Activation Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Developmental Process T Cell Costimulation Positive Regulation Of Leukocyte Differentiation T Cell Receptor Complex Intracellular Signaling Cassette CD8 Receptor Binding Nucleotide Binding Gamma-delta T Cell Activation Negative Regulation Of Cell Development Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phagocytosis Regulation Of Leukocyte Proliferation Response To Gamma Radiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Schaffer Collateral - CA1 Synapse	Cellular Response To Norepinephrine Stimulus Alpha-2B Adrenergic Receptor Binding Regulation Of Primary Metabolic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Response To Norepinephrine System Development Central Nervous System Development Identical Protein Binding Developmental Process Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Establishment Of Blood-nerve Barrier Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Transcription Repressor Complex Oxidative Stress-induced Premature Senescence Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition PML Body Glucose Catabolic Process To Lactate Via Pyruvate Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Fibroblast Proliferation Germ Cell Nucleus Cellular Response To Actinomycin D Negative Regulation Of Fibroblast Proliferation Regulation Of Transcription Initiation By RNA Polymerase II Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation NELF Complex Regulation Of Macromolecule Metabolic Process Nuclear Matrix Alpha-2A Adrenergic Receptor Binding Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
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