LIG4 and ATP6V0D1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		LIG4	ATP6V0D1
Gene Name		ligase IV, DNA, ATP-dependent	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Lysosomal Membrane Early Endosome Centrosome Synaptic Vesicle Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Axon Terminus Extracellular Vesicular Exosome
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	Protein Binding Hydrogen-exporting ATPase Activity, Phosphorylative Mechanism Protein Complex Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency	Cellular Iron Ion Homeostasis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Brain Development Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Endoplasmic Reticulum Unfolded Protein Response Transferrin Transport Cilium Assembly Cellular Protein Metabolic Process Interaction With Host Transmembrane Transport Phagosome Maturation
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle	Phagosomal maturation (early endosomal stage) Iron uptake and transport Transferrin endocytosis and recycling Insulin receptor recycling XBP1(S) activates chaperone genes IRE1alpha activates chaperones Latent infection of Homo sapiens with Mycobacterium tuberculosis Unfolded Protein Response (UPR) Signaling by Insulin receptor
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	2 interactors: ATXN1 LIG4
Entrez ID		3981	9114
HPRD ID		03500	06121
Ensembl ID		ENSG00000174405	ENSG00000159720
Uniprot IDs		P49917	F5GYQ1 P61421 R4GN72
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity	DNA Ligation Involved In DNA Recombination Response To Radiation Lagging Strand Elongation Pro-B Cell Differentiation Establishment Of Integrated Proviral Latency Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Viral Latency Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair T Cell Receptor V(D)J Recombination Lymphoid Progenitor Cell Differentiation DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Abiotic Stimulus Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion DNA Strand Elongation Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Response To Gamma Radiation Lung Alveolus Development Neuron Apoptotic Process Visual Learning Immunoglobulin Production Positive Regulation Of Fibroblast Proliferation Visual Behavior Neuron Death T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Associative Learning Nucleotide-excision Repair Regulation Of Fibroblast Proliferation DNA-dependent DNA Replication Adult Locomotory Behavior DNA Biosynthetic Process Membrane Depolarization Nuclear Export Cellular Response To Metal Ion Learning
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	arrested bones calcitonin cancellous cathepsin cd44 compensated connexin cx cx37 cx43 ex littermates metalloproteinase nfatc1 nonadherent notch osteoblast osteoblasts osteoclast osteoclasts osteocytes precursors rank rendered srankl stamp unchanged unrecognized
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	arrested bones calcitonin cancellous cathepsin cd44 compensated connexin cx cx37 cx43 ex littermates metalloproteinase nfatc1 nonadherent notch osteoblast osteoblasts osteoclast osteoclasts osteocytes precursors rank rendered srankl stamp unchanged unrecognized
Tagcloud (Intersection) ?