LIG4 and EIF2AK1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		LIG4	EIF2AK1
Gene Name		ligase IV, DNA, ATP-dependent	eukaryotic translation initiation factor 2-alpha kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Cytoplasm
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Heme Binding Protein Homodimerization Activity
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency	Response To Stress Negative Regulation Of Cell Proliferation Response To External Stimulus Regulation Of EIF2 Alpha Phosphorylation By Heme Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	4 interactors: CDC37 EIF2S1 HSP90AA1 LIG4
Entrez ID		3981	27102
HPRD ID		03500	10684
Ensembl ID		ENSG00000174405	ENSG00000086232
Uniprot IDs		P49917	B4DIP4 Q9BQI3
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity	DNA Ligation Involved In DNA Recombination Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Protein Folding Lagging Strand Elongation Pro-B Cell Differentiation Cellular Response To Stress Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Regulation Of Translational Initiation In Response To Stress DNA Ligation Involved In DNA Repair Protein Targeting Lymphoid Progenitor Cell Differentiation Posttranscriptional Regulation Of Gene Expression Chaperone-mediated Protein Complex Assembly DNA Ligation Regulation Of Translation In Response To Stress Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Protein Refolding Regulation Of Interferon-gamma-mediated Signaling Pathway Single Strand Break Repair Regulation Of Response To Interferon-gamma Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Catalytic Activity Isotype Switching Nitric Oxide Metabolic Process V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process DNA Strand Elongation Response To X-ray Regulation Of Protein Kinase Activity Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Kinase Activity Somatic Diversification Of Immunoglobulins Regulation Of Nitric-oxide Synthase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Regulation Of Immune Response B Cell Activation Involved In Immune Response Intracellular Protein Transport Intracellular Protein Transmembrane Transport Response To Gamma Radiation
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream
Tagcloud (Intersection) ?