SOCS3 and GHR

  • Number of citations of the paper that reports this interaction (PMID 10585430)
  • 43
  • Data Source:
  • HPRD (in vivo)

SOCS3

GHR

Gene Name suppressor of cytokine signaling 3 growth hormone receptor
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blood trace element (Se levels) ( 23720494)
  • Iron status biomarkers ( 19084217)
  • Response to taxane treatment (docetaxel) ( 23006423)
  • Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions 48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1 33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID 9021 2690
HPRD ID 05006 02971
Ensembl ID ENSG00000184557 ENSG00000112964
Uniprot IDs O14543 Q6FI39 P10912
PDB IDs 1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
activates  activator  ameliorate  attenuate  autoimmune  cd25lowcd44lowcd62lhigh  cd4  coculture  enhance  fate  h3k27me3  h3k4me3  immunomodulatory  immunoregulatory  inhibit  interferon  leading  manifestations  mesenchymal  msc  mscs  promoters  reciprocal  rorgammat  stat1  stat3  suppressors  th17  transducer 
becomes  ceptor  continuous  continuously  cwsv  dephosphorylation  eliminated  h7  internalization  involves  jak2  labile  lived  maintain  maximal  mg132  obligatory  ongoing  persisted  pervanadate  phosphotyrosine  proteasome  pulse  requirement  robust  stat5b  step  sustaining 
Tagcloud (Difference) ?
activates  activator  ameliorate  attenuate  autoimmune  cd25lowcd44lowcd62lhigh  cd4  coculture  enhance  fate  h3k27me3  h3k4me3  immunomodulatory  immunoregulatory  inhibit  interferon  leading  manifestations  mesenchymal  msc  mscs  promoters  reciprocal  rorgammat  stat1  stat3  suppressors  th17  transducer 
becomes  ceptor  continuous  continuously  cwsv  dephosphorylation  eliminated  h7  internalization  involves  jak2  labile  lived  maintain  maximal  mg132  obligatory  ongoing  persisted  pervanadate  phosphotyrosine  proteasome  pulse  requirement  robust  stat5b  step  sustaining 
Tagcloud (Intersection) ?