SOCS3 and RBMX

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS3	RBMX
Gene Name		suppressor of cytokine signaling 3	RNA binding motif protein, X-linked
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Membrane Ribonucleoprotein Complex Supraspliceosomal Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Nucleotide Binding Core Promoter Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Membrane Protein Ectodomain Proteolysis RNA Splicing Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Homooligomerization Cellular Response To Interleukin-1
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	34 interactors: APOBEC3C CCDC33 CIRBP CLK3 CSNK2A1 FAM103A1 FUS FXR2 HNRNPK IL7R ITSN2 JAK2 KHDRBS1 KHDRBS2 KHDRBS3 LNX1 MAGOHB NABP1 NFE2L2 PRR3 PSMF1 RBM3 RBM7 RBMY1A1 RBMY1F ROBO3 SNRPA SOCS3 SORBS3 SREK1 STAT5A TRA2B XRN1 ZNF490
Entrez ID		9021	27316
HPRD ID		05006	02186
Ensembl ID		ENSG00000184557	ENSG00000147274
Uniprot IDs		O14543 Q6FI39	P38159
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	MRNA Metabolic Process RNA Processing MRNA Processing Gene Expression RNA Splicing RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Gene Expression Response To Growth Hormone JAK-STAT Cascade Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Translation Positive Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Regulation Of RNA Splicing Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Response To Interferon-gamma Regulation Of Translation Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mitotic Cell Cycle Checkpoint Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Mast Cell Differentiation Recruitment Of MRNA Capping Enzyme To RNA Polymerase II Holoenzyme Complex Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Mitotic Cell Cycle Response To Cold Response To Cytokine Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Mineralocorticoid Receptor Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of RNA Export From Nucleus Cytokine-mediated Signaling Pathway
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 stella sublines talents vasa xq znf
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 stella sublines talents vasa xq znf
Tagcloud (Intersection) ?