GHR and GH1

Number of citations of the paper that reports this interaction (PubMedID 7862673)
30

Data Source:
BioGRID (pull down, pull down, biochemical)

		GHR	GH1
Description		growth hormone receptor	growth hormone 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Extracellular Matrix Endosome Lumen Vesicle Growth Hormone Receptor Complex
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding Protein Tyrosine Kinase Binding	Cytokine Activity Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding Growth Hormone Activity
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Gravity Response To Hormone Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Food Regulation Of Response To Nutrient Levels Response To Estradiol Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Response To Cytokine Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Response To Growth Hormone Response To Interleukin-1	Positive Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of D-glucose Transmembrane Transport Cytokine-mediated Signaling Pathway Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Bone Maturation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Somatotropin Pegvisomant Somatrem Somapacitan Lonapegsomatropin
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)	Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	7 interacting genes: GHR PRLR PSMD9 S100A6 S100P SHC1 TREM2
Entrez ID		2690	2688
HPRD ID		02971	00751
Ensembl ID		ENSG00000112964	ENSG00000259384
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	B1A4G6 B1A4G7 P01241
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD 6I5J 6I5N	1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR 6QIO
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Modification Process Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Via STAT Cytosol Protein Dephosphorylation Growth Hormone Receptor Binding Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Signal Transduction Protein Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Cul5-RING Ubiquitin Ligase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Protein Ubiquitination Insulin Receptor Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Regulation Of Cell Communication Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Regulation Of Cell Adhesion Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Lipid Binding Peptide Hormone Binding Extracellular Region Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine Receptor Activity Response To Bacterium Calcium-dependent Protein Binding Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Growth Hormone Receptor Activity Positive Regulation Of MAPK Cascade Prolactin Receptor Activity Shc-EGFR Complex Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Peptidoglycan Regulation Of Engulfment Of Apoptotic Cell Growth Hormone Receptor Complex Response To Cycloheximide Regulation Of MAPK Cascade Protein Homodimerization Activity Plasma Membrane Hormone-mediated Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Proteasome Regulatory Particle Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Cell Proliferation In Bone Marrow Phospholipid Binding Epidermal Growth Factor Binding Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of ERK1 And ERK2 Cascade Neurotrophin TRKA Receptor Binding Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway
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