SOCS3 and IL12RB2

Number of citations of the paper that reports this interaction (PMID 14559241)
26

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SOCS3	IL12RB2
Gene Name		suppressor of cytokine signaling 3	interleukin 12 receptor, beta 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Cytokine Receptor Activity Protein Kinase Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Interferon-gamma Production Positive Regulation Of Interferon-gamma Production
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)	Behcet's disease ( 20622878 20622879) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	5 interactors: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		9021	3595
HPRD ID		05006	03383
Ensembl ID		ENSG00000184557	ENSG00000081985
Uniprot IDs		O14543 Q6FI39	B4DGA4 Q99665
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Cytokine Stimulus Response To Interferon-gamma Response To Cytokine Interleukin-12-mediated Signaling Pathway JAK-STAT Cascade Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Regulation Of JAK-STAT Cascade Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Cellular Response To Organic Substance Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Innate Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Response To Organic Substance Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?