SOCS3 and IL12RB2

Number of citations of the paper that reports this interaction (PubMedID 14559241)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SOCS3	IL12RB2
Description		suppressor of cytokine signaling 3	interleukin 12 receptor subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Side Of Plasma Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding	Cytokine Receptor Activity Coreceptor Activity Protein Kinase Binding Cytokine Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Response To Cytokine Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576) Crohn's disease ( 22412388 28067908) Crohn's disease or systemic sclerosis ( 32024964) Inflammatory bowel disease ( 23128233 28067908) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 20639880 21399635 26394269 19458352) Rheumatoid arthritis ( 32868391) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 28714469 33536424 26502338 19838195) Systemic sclerosis ( 29293537 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)
Interacting Genes		66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		9021	3595
HPRD ID		05006	03383
Ensembl ID		ENSG00000184557	ENSG00000081985
Uniprot IDs		O14543 Q6FI39	A0A8Q3SIX0 B4DGA4 B7ZB60 Q99665
PDB IDs			8XRP 8YI7
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation	Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation Interleukin-12 Receptor Binding T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Via STAT Alpha-beta T Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Lymphocyte Activation Involved In Immune Response T Cell Differentiation Leukocyte Activation Involved In Immune Response Response To Cytokine Cell Activation Involved In Immune Response Response To Peptide Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Lymphocyte Differentiation Interleukin-23 Receptor Complex T Cell Activation Mononuclear Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Interleukin-23-mediated Signaling Pathway Leukocyte Differentiation Immune Effector Process Cellular Response To Cytokine Stimulus Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T Cell Proliferation Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Lymphocyte Activation Regulation Of Type II Interferon Production Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of Cell Fate Commitment Leukocyte Activation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation
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