SOCS3 and ACADVL

Number of citations of the paper that reports this interaction (PMID 22093833)
2

Data Source:
BioGRID (pull down)

		SOCS3	ACADVL
Gene Name		suppressor of cytokine signaling 3	acyl-CoA dehydrogenase, very long chain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Nucleoid
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Acyl-CoA Dehydrogenase Activity Long-chain-acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation	Temperature Homeostasis Fatty Acid Beta-oxidation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Cellular Lipid Metabolic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin	Fatty acid, triacylglycerol, and ketone body metabolism IRE1alpha activates chaperones Metabolism of lipids and lipoproteins Mitochondrial Fatty Acid Beta-Oxidation mitochondrial fatty acid beta-oxidation of saturated fatty acids XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	3 interactors: GPHN RPSA SOCS3
Entrez ID		9021	37
HPRD ID		05006	01940
Ensembl ID		ENSG00000184557	ENSG00000072778
Uniprot IDs		O14543 Q6FI39	B3KPA6 P49748
PDB IDs			2UXW 3B96
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Establishment Of Synaptic Specificity At Neuromuscular Junction Spongiotrophoblast Differentiation Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Transport RRNA 3'-end Processing Protein Localization To Membrane Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Ribosomal Small Subunit Assembly Branching Involved In Labyrinthine Layer Morphogenesis Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Spongiotrophoblast Layer Development Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of JAK-STAT Cascade Labyrinthine Layer Morphogenesis Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Postsynaptic Membrane Organization Embryonic Placenta Morphogenesis Ribosome Assembly Maturation Of SSU-rRNA Membrane Organization Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Negative Regulation Of Insulin Receptor Signaling Pathway Ribosomal Small Subunit Biogenesis Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Protein Metabolic Process Receptor Clustering Neuromuscular Junction Development JAK-STAT Cascade Labyrinthine Layer Development Regulation Of Insulin Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Export From Nucleus Cellular Protein Localization Synapse Assembly Regulation Of Cellular Response To Insulin Stimulus Water-soluble Vitamin Metabolic Process
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	2t 390del 7123997t acyl boy coa decompensation deterioration diagnose downhill glu130del hong illustrates inborn kong lives newborn obviated opportunity prompt save siblings succumbed sudden tandem treatable unexpected urge vlcad
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	2t 390del 7123997t acyl boy coa decompensation deterioration diagnose downhill glu130del hong illustrates inborn kong lives newborn obviated opportunity prompt save siblings succumbed sudden tandem treatable unexpected urge vlcad
Tagcloud (Intersection) ?