SOCS3 and EPOR

Number of citations of the paper that reports this interaction (PMID 10882725)
53

Data Source:
HPRD (in vitro, in vivo)

		SOCS3	EPOR
Gene Name		suppressor of cytokine signaling 3	erythropoietin receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin
Drugs			Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1
Entrez ID		9021	2057
HPRD ID		05006	00587
Ensembl ID		ENSG00000184557	ENSG00000187266
Uniprot IDs		O14543 Q6FI39	P19235
PDB IDs			1CN4 1EBA 1EBP 1EER 1ERN 2JIX
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Intersection) ?