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SOCS3 and CXCR4
Number of citations of the paper that reports this interaction (PubMedID
12163560
)
56
Data Source:
HPRD
(in vitro, in vivo)
SOCS3
CXCR4
Description
suppressor of cytokine signaling 3
C-X-C motif chemokine receptor 4
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Cytoplasmic Side Of Plasma Membrane
Cytoplasm
Lysosome
Endosome
Early Endosome
Late Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Leading Edge
Cytoplasmic Vesicle
Protein-containing Complex
Extracellular Exosome
Anchoring Junction
Molecular Function
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Cytokine Receptor Binding
Protein Binding
Protein Tyrosine Kinase Inhibitor Activity
MiRNA Binding
Virus Receptor Activity
Actin Binding
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-X-C Chemokine Receptor Activity
Cytokine Binding
C-C Chemokine Binding
Ubiquitin Protein Ligase Binding
Myosin Light Chain Binding
C-X-C Motif Chemokine 12 Receptor Activity
Ubiquitin Binding
Biological Process
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Cell Differentiation
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Interleukin-6-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cellular Response To Interleukin-17
Cellular Response To Leukemia Inhibitory Factor
Response To Hypoxia
Dendritic Cell Chemotaxis
Apoptotic Process
Chemotaxis
Inflammatory Response
Immune Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Brain Development
Response To Virus
Cell Migration
Calcium-mediated Signaling
Neurogenesis
Regulation Of Cell Adhesion
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
CXCL12-activated CXCR4 Signaling Pathway
Myelin Maintenance
Symbiont Entry Into Host Cell
Positive Regulation Of Oligodendrocyte Differentiation
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Vasculature Development
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Binding and entry of HIV virion
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
Formation of definitive endoderm
Specification of primordial germ cells
Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Baclofen
Framycetin
AMD-070
Plerixafor
Ulocuplumab
Ibalizumab
MSX-122
Diseases
Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Albumin-globulin ratio (
29403010
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Arthritis (juvenile idiopathic) (
27005825
)
Attention deficit hyperactivity disorder (
32595297
)
Body mass index (
26426971
)
Colorectal cancer (
29228715
)
Estimated glomerular filtration rate (
31152163
)
Lung function (low FEV1 vs high FEV1) (
26423011
)
Monocyte count (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Multiple sclerosis (
19525953
31604244
)
Non-albumin protein levels (
29403010
)
Smoking status (ever vs never smokers) (
30643258
)
Telomere length (
20421499
)
White blood cell count (
32888494
)
Interacting Genes
66 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CAVIN1
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
MEX3C
NFATC2
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
34 interacting genes:
ARRB2
ATP13A2
B2M
CCR5
CD4
CTSG
CXCL12
DPP4
DUXAP9
ELANE
GNA13
GNAI1
GRK3
HSPA8
ITCH
JAK1
JAK2
JAK3
MYBL2
MYH9
PTK2
PTPN11
PTPN6
PTPRC
RNF113A
SDC4
SOCS1
SOCS3
STAT1
STAT2
STAT3
STAT5B
USP14
VAV1
Entrez ID
9021
7852
HPRD ID
05006
01217
Ensembl ID
ENSG00000184557
ENSG00000121966
Uniprot IDs
O14543
Q6FI39
A0A0U3FJG0
A0A0U3GXA9
A0A8Q3WLL1
P61073
PDB IDs
2K03
2K04
2K05
2N55
3ODU
3OE0
3OE6
3OE8
3OE9
4RWS
8GP3
8I0Q
8K3Z
8U4N
8U4O
8U4P
8U4Q
8U4R
8U4S
8U4T
8YU7
8ZPL
8ZPM
8ZPN
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Receptor Complex
Signal Transduction
Protein Kinase Activity
Kinase Activity
Cytokine-mediated Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphorylation
Positive Regulation Of Cell Communication
Cytokine Binding
Phosphorylation
Negative Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Epidermal Growth Factor Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytokine Receptor Activity
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
ERBB Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Apoptotic Process
External Side Of Plasma Membrane
Regulation Of Programmed Cell Death
Protein Modification Process
Erythropoietin-mediated Signaling Pathway
Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Immune System Process
Intracellular Signaling Cassette
Cell Differentiation
Positive Regulation Of Cell Motility
Cellular Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Locomotion
Protein Autophosphorylation
Regulation Of Cell-cell Adhesion
Cytokine-mediated Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Immune System Process
Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of T Cell Activation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Growth Hormone Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Adhesion
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Activation
Regulation Of Defense Response
Positive Regulation Of T Cell Activation
Response To Stress
Defense Response
Positive Regulation Of Immune System Process
Interleukin-9-mediated Signaling Pathway
Negative Regulation Of Immune System Process
Positive Regulation Of Multicellular Organismal Process
Response To Other Organism
Cell Activation
Immune System Process
Negative Regulation Of Leukocyte Cell-cell Adhesion
Response To External Biotic Stimulus
Regulation Of Cytokine Production
Interleukin-15-mediated Signaling Pathway
Leukocyte Activation
Positive Regulation Of Lymphocyte Activation
Regulation Of T Cell Proliferation
Cell Migration
Regulation Of Leukocyte Proliferation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Population Proliferation
Negative Regulation Of Leukocyte Activation
Positive Regulation Of Cell Activation
Leukocyte Mediated Cytotoxicity
T Cell Activation
Negative Regulation Of T Cell Activation
Positive Regulation Of Immune Response
Regulation Of Developmental Process
Interleukin-6-mediated Signaling Pathway
Regulation Of Multicellular Organismal Process
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Tagcloud (Intersection)
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