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SOCS3 and GFRA1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
SOCS3
GFRA1
Description
suppressor of cytokine signaling 3
GDNF family receptor alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Cytoplasmic Side Of Plasma Membrane
Extracellular Space
Endosome
Multivesicular Body
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Extrinsic Component Of Membrane
Axon
Neuronal Cell Body
Receptor Complex
Extracellular Exosome
Side Of Membrane
Plasma Membrane Protein Complex
Molecular Function
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Cytokine Receptor Binding
Protein Binding
Protein Tyrosine Kinase Inhibitor Activity
MiRNA Binding
Neurotrophin Receptor Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
Glial Cell-derived Neurotrophic Factor Receptor Activity
Signaling Receptor Activity
Biological Process
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Cell Differentiation
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Interleukin-6-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cellular Response To Interleukin-17
Cellular Response To Leukemia Inhibitory Factor
Kidney Development
Cell Surface Receptor Signaling Pathway
Nervous System Development
Male Gonad Development
Cell Migration
Neuron Differentiation
Neuron Projection Development
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Pathways
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
NCAM1 interactions
RAF/MAP kinase cascade
RET signaling
Formation of the ureteric bud
Drugs
Diseases
GWAS
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Blood protein levels (
30072576
)
Delirium (
29631748
)
Epilepsy and lamotrigine-induced maculopapular eruptions (
26220383
)
Malaria (
31844061
)
Migraine without aura (
28952330
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Interacting Genes
66 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CAVIN1
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
MEX3C
NFATC2
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
5 interacting genes:
GDNF
NCAM1
NRTN
RET
SOCS3
Entrez ID
9021
2674
HPRD ID
05006
03291
Ensembl ID
ENSG00000184557
ENSG00000151892
Uniprot IDs
O14543
Q6FI39
B7Z856
P56159
PDB IDs
6Q2N
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Receptor Complex
Signal Transduction
Protein Kinase Activity
Kinase Activity
Cytokine-mediated Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphorylation
Positive Regulation Of Cell Communication
Cytokine Binding
Phosphorylation
Negative Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Epidermal Growth Factor Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytokine Receptor Activity
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
ERBB Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Apoptotic Process
External Side Of Plasma Membrane
Regulation Of Programmed Cell Death
Protein Modification Process
Erythropoietin-mediated Signaling Pathway
Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Immune System Process
Intracellular Signaling Cassette
Cell Differentiation
Positive Regulation Of Cell Motility
Cellular Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Locomotion
Protein Autophosphorylation
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Glial Cell-derived Neurotrophic Factor Receptor Binding
Neural Crest Cell Migration
Regulation Of Semaphorin-plexin Signaling Pathway
Mesenchymal Cell Migration
Neuron Projection Development
Ameboidal-type Cell Migration
Enteric Nervous System Development
Commissural Neuron Axon Guidance
Embryonic Epithelial Tube Formation
Neuron Projection Guidance
Axon Guidance
Plasma Membrane Bounded Cell Projection Organization
Epithelial Tube Formation
Metanephros Development
Regulation Of Kidney Development
Ureteric Bud Development
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Mesonephric Epithelium Development
Mesonephric Tubule Development
Cell Projection Organization
Receptor Tyrosine Kinase Binding
Tissue Morphogenesis
Kidney Epithelium Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Nervous System Development
Enzyme-linked Receptor Protein Signaling Pathway
Chemoattractant Activity Involved In Axon Guidance
Postganglionic Parasympathetic Fiber Development
Tube Formation
Posterior Midgut Development
Morphogenesis Of A Branching Structure
Regulation Of Extrinsic Apoptotic Signaling Pathway
Growth Factor Activity
Morphogenesis Of A Branching Epithelium
Cell Surface Receptor Signaling Pathway
Chemoattraction Of Axon
Peyer's Patch Morphogenesis
Positive Regulation Of Metanephric Glomerulus Development
Kidney Development
Positive Regulation Of Ureteric Bud Formation
Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Ureter Maturation
Autonomic Nervous System Development
Ureteric Bud Formation
Cell Migration
Dorsal Spinal Cord Development
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Glomerulus Development
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Tagcloud (Difference)
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Tagcloud (Intersection)
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