SOCS3 and GFRA1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SOCS3	GFRA1
Name		suppressor of cytokine signaling 3	GDNF family receptor alpha 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Side Of Plasma Membrane	Extracellular Space Endosome Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Axon Neuronal Cell Body Receptor Complex Extracellular Exosome Side Of Membrane Plasma Membrane Protein Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding	Neurotrophin Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor	Kidney Development Cell Surface Receptor Signaling Pathway Nervous System Development Male Gonad Development Cell Migration Neuron Differentiation Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud
GWAS		Asthma ( 32296059 ) Blood trace element (Se levels) ( 23720494 ) Creatine kinase levels ( 29403010 )	Blood protein levels ( 30072576 ) Delirium ( 29631748 ) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383 ) Malaria ( 31844061 ) Migraine without aura ( 28952330 ) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603 )
Interacting Genes		66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	5 interacting genes: GDNF NCAM1 NRTN RET SOCS3
Entrez ID		9021	2674
HPRD ID		05006	03291
Ensembl ID		ENSG00000184557	ENSG00000151892
Uniprot IDs		O14543 Q6FI39	B7Z856 P56159
PDB IDs		Not available	6Q2N
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Binding Neural Crest Cell Migration Regulation Of Semaphorin-plexin Signaling Pathway Mesenchymal Cell Migration Neuron Projection Development Ameboidal-type Cell Migration Enteric Nervous System Development Commissural Neuron Axon Guidance Embryonic Epithelial Tube Formation Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Epithelial Tube Formation Metanephros Development Regulation Of Kidney Development Ureteric Bud Development Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesonephric Epithelium Development Mesonephric Tubule Development Cell Projection Organization Receptor Tyrosine Kinase Binding Tissue Morphogenesis Kidney Epithelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Tube Formation Posterior Midgut Development Morphogenesis Of A Branching Structure Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Factor Activity Morphogenesis Of A Branching Epithelium Cell Surface Receptor Signaling Pathway Chemoattraction Of Axon Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Kidney Development Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Ureter Maturation Autonomic Nervous System Development Ureteric Bud Formation Cell Migration Dorsal Spinal Cord Development GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development