SOCS3 and KIAA1958

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SOCS3	KIAA1958
Gene Name		suppressor of cytokine signaling 3	KIAA1958
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	11 interactors: AQP1 CEP19 COASY FAM124B GABARAPL2 LMO4 MCRS1 RWDD2B SOCS3 STAC TCEA2
Entrez ID		9021	158405
HPRD ID		05006	11173
Ensembl ID		ENSG00000184557	ENSG00000165185
Uniprot IDs		O14543 Q6FI39	B7ZKW6 Q8N8K9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Corticotropin Secretion Carbon Dioxide Transmembrane Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cellular Response To Mercury Ion Metanephric Proximal Convoluted Tubule Development Nitric Oxide Transport Metanephric Proximal Tubule Development Spongiotrophoblast Differentiation Cellular Response To Stress Purine Nucleotide Biosynthetic Process Positive Regulation Of Saliva Secretion Renal Water Absorption Carbon Dioxide Transport Epithelial Fluid Transport Ribose Phosphate Biosynthetic Process Renal Water Transport Cellular Response To Copper Ion Regulation Of Saliva Secretion Pancreatic Juice Secretion Proximal Tubule Development Negative Regulation Of Cellular Protein Metabolic Process Metanephric Loop Of Henle Development Cerebrospinal Fluid Secretion Cardiovascular System Development Cellular Hyperosmotic Response Hyperosmotic Salinity Response Negative Regulation Of Protein Metabolic Process Metanephric Glomerulus Vasculature Development Glycerol Transport Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Salt Stress Pantothenate Metabolic Process Positive Regulation Of Digestive System Process Response To Stress Renal Absorption Loop Of Henle Development Lipid Digestion Histone H4-K5 Acetylation Histone H4-K8 Acetylation Polyol Transport Cellular Response To Nitric Oxide Ribonucleotide Metabolic Process Transepithelial Transport Cellular Water Homeostasis Nucleotide Biosynthetic Process
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer
Tagcloud (Intersection) ?