SOCS3 and PIN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SOCS3	PIN1
Gene Name		suppressor of cytokine signaling 3	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Midbody
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Phosphoserine Binding Phosphothreonine Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation	Protein Peptidyl-prolyl Isomerization Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Motility
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	184 interactors: ABI2 ADAMTSL4 ADARB1 AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ATP5B BAG6 BCL2 BCL6 BCLAF1 CAPRIN1 CARHSP1 CASP6 CBS CCDC184 CCDC33 CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 EFTUD2 EIF3G EP300 ETV6 FASLG FOXO4 FOXP2 G3BP1 G3BP2 GGA2 GOLGA2 GPAA1 GPHN HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ IKZF1 IKZF3 JAKMIP2 JUN KIAA1429 KIF20B KIF5A KLHL20 KMT2B KRT31 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX2 MOCS1 MTFR1 MTUS2 MYT1 NAB2 NCOA3 NEK6 NFATC2 NONO NUP62 PABPC1 PKIB PKM PKMYT1 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS RAB4A RAF1 RAI1 RARA RBBP8 RBPMS RELA REPS1 RNPS1 RPL4 RPS6KB1 SFPQ SHKBP1 SMAD3 SNRNP200 SOCS3 SPERT SREK1 SRRM1 SRRM2 SRSF11 SSBP3 STIL SUPT5H TAB3 TBC1D4 TCF4 TFG THAP7 THRAP3 TLE3 TNIP1 TOP2A TP53 TP73 TRAF1 TRAF2 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN4 UNC119 WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB22 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446
Entrez ID		9021	5300
HPRD ID		05006	03031
Ensembl ID		ENSG00000184557	ENSG00000127445
Uniprot IDs		O14543 Q6FI39	Q13526
PDB IDs			1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M9E 2M9F 2M9I 2M9J 2Q5A 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle RNA Processing Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Death Death Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated MRNA Processing Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes
Tagcloud (Intersection) ?