GHR and PTPRB

Number of citations of the paper that reports this interaction (PMID 12907755)
14

Data Source:
BioGRID (pull down)

		GHR	PTPRB
Gene Name		growth hormone receptor	protein tyrosine phosphatase, receptor type, B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatropin recombinant Pegvisomant
Diseases
GWAS		Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2	10 interactors: CDH5 CNTN1 CNTNAP1 F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		2690	5787
HPRD ID		02971	01474
Ensembl ID		ENSG00000112964	ENSG00000127329
Uniprot IDs		P10912	B7ZKS8 F5H3G6 P23467 Q86VA4
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway	Cell Adhesion Signaling Cell Communication Cell Development Axon Development Locomotion Neuronal Action Potential Propagation Cell Morphogenesis Involved In Differentiation Neuron Projection Development Movement Of Cell Or Subcellular Component Axon Guidance Mesenchymal-epithelial Cell Signaling Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Kinase Activity Cell Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Organization Positive Regulation Of Transferase Activity Cell Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Stimulus Cell-cell Junction Organization Positive Regulation Of MAP Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Establishment Or Maintenance Of Cell Polarity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Signal Transduction Endothelial Cell Development Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Generation Of Neurons Developmental Process Positive Regulation Of Intracellular Signal Transduction Transmission Of Nerve Impulse
Tagcloud ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining	accumulative acknowledged astrocytoma chi3l1 chr1 chr22 clustering crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline
Tagcloud (Difference) ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining	accumulative acknowledged astrocytoma chi3l1 chr1 chr22 clustering crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline
Tagcloud (Intersection) ?