GHR and JAK2

  • Number of citations of the paper that reports this interaction (PMID 7540178)
  • 27
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical)
  • HPRD (in vivo)

GHR

JAK2

Gene Name growth hormone receptor Janus kinase 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Iron status biomarkers ( 19084217)
  • Response to taxane treatment (docetaxel) ( 23006423)
  • Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions 33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2 94 interactors: ABL1 AGTR1 ASS1 BCR BRCA1 CCR5 CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I HES1 HES5 HIST3H3 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1
Entrez ID 2690 3717
HPRD ID 02971 00993
Ensembl ID ENSG00000112964 ENSG00000096968
Uniprot IDs P10912 O60674
PDB IDs 1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
becomes  ceptor  continuous  continuously  cwsv  dephosphorylation  eliminated  h7  internalization  involves  jak2  labile  lived  maintain  maximal  mg132  obligatory  ongoing  persisted  pervanadate  phosphotyrosine  proteasome  pulse  requirement  robust  stat5b  step  sustaining 
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
Tagcloud (Difference) ?
becomes  ceptor  continuous  continuously  cwsv  dephosphorylation  eliminated  h7  internalization  involves  labile  lived  maintain  maximal  mg132  obligatory  ongoing  persisted  pervanadate  phosphotyrosine  proteasome  pulse  requirement  robust  stat5b  step  sustaining 
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
Tagcloud (Intersection) ?
jak2