GHR and JAK2

Number of citations of the paper that reports this interaction (PubMedID 21347402)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (in vivo)

		GHR	JAK2
Description		growth hormone receptor	Janus kinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex	Euchromatin Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Caveola Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Endosome Lumen Interleukin-12 Receptor Complex Membrane Raft Interleukin-23 Receptor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Growth Hormone Receptor Binding Interleukin-12 Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heme Binding Signaling Receptor Activator Activity Type 1 Angiotensin Receptor Binding Acetylcholine Receptor Binding Histone H3Y41 Kinase Activity SH2 Domain Binding Histone Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding Metal Ion Binding Peptide Hormone Receptor Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Gravity Response To Hormone Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Food Regulation Of Response To Nutrient Levels Response To Estradiol Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Response To Cytokine Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Response To Growth Hormone Response To Interleukin-1	Microglial Cell Activation Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Apoptotic Process Immune Response Response To Oxidative Stress Cell Adhesion Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Mesoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hormone-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell-substrate Adhesion Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Actin Filament Polymerization Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cell Migration Axon Regeneration Lipopolysaccharide-mediated Signaling Pathway Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Proliferation Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Response To Tumor Necrosis Factor Post-embryonic Hemopoiesis Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Collagen-activated Signaling Pathway Interleukin-23-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Erythropoietin-mediated Signaling Pathway Thrombopoietin-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Response To Antibiotic Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Inflammatory Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Activation Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type II Interferon-mediated Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Epithelium Development Interleukin-6-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Response To Interleukin-12 Interleukin-35-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Dexamethasone Stimulus Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of Cold-induced Thermogenesis Defense Response To Symbiont Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Platelet Aggregation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Postsynapse To Nucleus Signaling Pathway Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Prolactin receptor signaling Prolactin receptor signaling Signaling by SCF-KIT Signaling by Leptin RMTs methylate histone arginines Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF activation RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cyclin D associated events in G1 Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-35 Signalling Signaling by Erythropoietin Signaling by Erythropoietin Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling IFNG signaling activates MAPKs Growth hormone receptor signaling Growth hormone receptor signaling Factors involved in megakaryocyte development and platelet production
Drugs		Somatotropin Pegvisomant Somatrem Somapacitan Lonapegsomatropin	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one XL019 5-phenyl-1H-indazol-3-amine 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM Ruxolitinib Tofacitinib Pacritinib Baricitinib Entrectinib Fostamatinib Fedratinib Abrocitinib Zanubrutinib Pralsetinib
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Polycythemia vera
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 23266558) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Eosinophilic esophagitis ( 34506852) HDL cholesterol ( 30275531) Height ( 31562340) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 30275531) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 19287384 25849990 33057200) Neutrophil count ( 32888494) Pediatric autoimmune diseases ( 26301688) Platelet count ( 24777453 32888494 27863252 28031487) Plateletcrit ( 27863252 32888494) Psoriatic arthritis ( 26626624) Red blood cell count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Total cholesterol levels ( 30275531) Ulcerative colitis ( 19915573 20228799 21297633 26398853) White blood cell count ( 32888494)
Interacting Genes		44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	99 interacting genes: ABL1 AGTR1 ARL11 ASS1 BCR BRCA1 CBL CCR5 CISH CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I H3-4 HES1 HES5 HSFY1 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK1 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1
Entrez ID		2690	3717
HPRD ID		02971	00993
Ensembl ID		ENSG00000112964	ENSG00000096968
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	A8K910 B4DYV1 O60674
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD 6I5J 6I5N	2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4C61 4C62 4D0W 4D0X 4D1S 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA 4P7E 4YTC 4YTF 4YTH 4YTI 4Z32 4ZIM 5AEP 5CF4 5CF5 5CF6 5CF8 5HEZ 5I4N 5L3A 5TQ3 5TQ4 5TQ5 5TQ6 5TQ7 5TQ8 5USY 5USZ 5UT0 5UT1 5UT2 5UT3 5UT4 5UT5 5UT6 5WEV 5WIJ 5WIK 5WIL 5WIM 5WIN 6AAJ 6BBV 6BRW 6BS0 6BSS 6D2I 6DRW 6E2P 6E2Q 6G3C 6M9H 6OAV 6OBB 6OBF 6OBL 6OCC 6TPD 6VGL 6VN8 6VNB 6VNC 6VNE 6VNF 6VNG 6VNH 6VNI 6VNJ 6VNK 6VNL 6VNM 6VS3 6VSN 6WTN 6WTO 6WTP 6WTQ 6X8E 6XJK 7F7W 7JYO 7JYQ 7LL4 7LL5 7Q7I 7Q7K 7Q7L 7Q7W 7REE 7RN6 7SZW 7T0P 7T1T 7TEU 7UYW 8B8N 8B8U 8B99 8B9E 8B9H 8BA2 8BA3 8BA4 8BAB 8BAK 8BM2 8BPV 8BPW 8BX6 8BX9 8BXC 8BXH 8C08 8C09 8C0A 8CZ9 8EX0 8EX1 8EX2 8EXK 8EYA 8EYB 8F88 8G6Z 8G8O 8G8X
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Modification Process Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Via STAT Cytosol Protein Dephosphorylation Growth Hormone Receptor Binding Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Signal Transduction Protein Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Cul5-RING Ubiquitin Ligase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Protein Ubiquitination Insulin Receptor Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Regulation Of Cell Communication Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Regulation Of Cell Adhesion Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Cytokine Receptor Activity Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Receptor Complex Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Plasma Membrane Regulation Of Signaling Regulation Of Cell Communication Protein Tyrosine Kinase Activity Immune System Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cytokine Binding Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Positive Regulation Of Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Activation Cell Activation Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Regulation Of Cell Development Positive Regulation Of Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Phosphotyrosine Residue Binding Positive Regulation Of Cell Activation Growth Hormone Receptor Signaling Pathway Leukocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Hemopoiesis Regulation Of MAPK Cascade Regulation Of Programmed Cell Death Response To Cytokine Regulation Of T Cell Activation
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