GHR and TYK2

  • Number of citations of the paper that reports this interaction (PMID 10502458)
  • 2
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo)

GHR

TYK2

Gene Name growth hormone receptor tyrosine kinase 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Iron status biomarkers ( 19084217)
  • Response to taxane treatment (docetaxel) ( 23006423)
  • Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions 33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2 36 interactors: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR GNB2L1 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5
Entrez ID 2690 7297
HPRD ID 02971 01490
Ensembl ID ENSG00000112964 ENSG00000105397
Uniprot IDs P10912 P29597
PDB IDs 1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
becomes  ceptor  continuous  continuously  cwsv  dephosphorylation  eliminated  h7  internalization  involves  jak2  labile  lived  maintain  maximal  mg132  obligatory  ongoing  persisted  pervanadate  phosphotyrosine  proteasome  pulse  requirement  robust  stat5b  step  sustaining 
3t3  carboxyl  coimmunoprecipitated  directed  f442a  functionally  gh  ghr  heretofore  hmw  immunoblotting  immunologically  immunoprecipitation  independently  jak1  jak2  jak3  janus  kd  member  mr  physically  preadipocytes  referred  signalling  step  terminus  tyrosine  whose 
Tagcloud (Difference) ?
becomes  ceptor  continuous  continuously  cwsv  dephosphorylation  eliminated  h7  internalization  involves  labile  lived  maintain  maximal  mg132  obligatory  ongoing  persisted  pervanadate  phosphotyrosine  proteasome  pulse  requirement  robust  stat5b  sustaining 
3t3  carboxyl  coimmunoprecipitated  directed  f442a  functionally  heretofore  hmw  immunoblotting  immunologically  immunoprecipitation  independently  jak1  jak3  janus  kd  member  mr  physically  preadipocytes  referred  signalling  terminus  tyrosine  whose 
Tagcloud (Intersection) ?
gh  ghr  jak2  step