GHR and PTPRH

Number of citations of the paper that reports this interaction (PMID 12907755)
14

Data Source:
BioGRID (pull down, far western blotting)

		GHR	PTPRH
Gene Name		growth hormone receptor	protein tyrosine phosphatase, receptor type, H
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex	Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Protein Dephosphorylation Apoptotic Process Peptidyl-tyrosine Dephosphorylation
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatropin recombinant Pegvisomant
Diseases
GWAS		Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2	11 interactors: BCAR1 DHPS DOK1 GHR KRTAP10-3 KRTAP10-8 LCK MAPK1 MLH1 PTK2 PXN
Entrez ID		2690	5794
HPRD ID		02971	03942
Ensembl ID		ENSG00000112964	ENSG00000080031
Uniprot IDs		P10912	C9JCH2 Q9HD43
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Hormone Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organonitrogen Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification B Cell Receptor Signaling Pathway Platelet Activation Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Signal Complex Assembly Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Antigen Receptor-mediated Signaling Pathway Activation Of MAPK Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transferase Activity
Tagcloud ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Difference) ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Intersection) ?