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SOCS3 and IRS2
Number of citations of the paper that reports this interaction (PubMedID
15514089
)
0
Data Source:
HPRD
(in vivo)
SOCS3
IRS2
Description
suppressor of cytokine signaling 3
insulin receptor substrate 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Cytoplasmic Side Of Plasma Membrane
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Cytokine Receptor Binding
Protein Binding
Protein Tyrosine Kinase Inhibitor Activity
MiRNA Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Phosphatidylinositol 3-kinase Binding
14-3-3 Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Cell Differentiation
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Interleukin-6-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cellular Response To Interleukin-17
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of B Cell Apoptotic Process
Glucose Metabolic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Brain Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Response To Glucose
Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Cell Migration
Regulation Of Lipid Metabolic Process
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Insulin Secretion
Cellular Response To Insulin Stimulus
Type B Pancreatic Cell Proliferation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transport
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lipid Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Endothelin
Pathways
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
PI3K/AKT activation
Constitutive Signaling by Aberrant PI3K in Cancer
IRS-related events triggered by IGF1R
Signaling by Leptin
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Growth hormone receptor signaling
Drugs
Diseases
GWAS
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Alanine aminotransferase levels (
34315874
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Aspartate aminotransferase levels (
34315874
)
Heel bone mineral density (
28869591
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High light scatter reticulocyte count (
32888494
)
Insulin-related traits (multivariate analysis) (
32002517
)
Mean corpuscular hemoglobin (
27863252
29403010
32888494
)
Mean corpuscular volume (
27863252
32888494
29403010
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Nose size (
27182965
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Platelet count (
29403010
)
Prostate cancer (
29117387
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Type 2 diabetes (
30297969
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
White matter lesion progression (
26451028
)
White matter lesion progression (adjusted for white matter lesion burden at baseline) (
26451028
)
Interacting Genes
66 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CAVIN1
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
MEX3C
NFATC2
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
40 interacting genes:
AP2M1
ATP2A1
ATP2A2
BCL2L1
CRK
EPOR
FES
GRB2
IGF1R
IL4R
INSR
JAK1
JAK2
JAK3
MPL
MTDH
NEDD4
NTRK1
PIK3CA
PIK3CD
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
PTPN6
PTPRF
RPTOR
SHC1
SOCS1
SOCS3
SOCS6
SOCS7
SRPK2
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAZ
Entrez ID
9021
8660
HPRD ID
05006
02878
Ensembl ID
ENSG00000184557
ENSG00000185950
Uniprot IDs
O14543
Q6FI39
Q9P084
Q9Y4H2
PDB IDs
3FQW
3FQX
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Receptor Complex
Signal Transduction
Protein Kinase Activity
Kinase Activity
Cytokine-mediated Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphorylation
Positive Regulation Of Cell Communication
Cytokine Binding
Phosphorylation
Negative Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Epidermal Growth Factor Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytokine Receptor Activity
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
ERBB Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Apoptotic Process
External Side Of Plasma Membrane
Regulation Of Programmed Cell Death
Protein Modification Process
Erythropoietin-mediated Signaling Pathway
Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Immune System Process
Intracellular Signaling Cassette
Cell Differentiation
Positive Regulation Of Cell Motility
Cellular Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Locomotion
Protein Autophosphorylation
Signal Transduction
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Phosphotyrosine Residue Binding
Protein Modification Process
Insulin Receptor Substrate Binding
Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Binding
Protein Phosphorylation
Phosphatidylinositol 3-kinase Complex, Class IA
Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Adhesion
Phosphorylation
Regulation Of Immune System Process
Regulation Of Cell Communication
Regulation Of Signaling
Cytokine-mediated Signaling Pathway
Regulation Of Cellular Localization
Negative Regulation Of Immune System Process
Immune System Process
Phosphate-containing Compound Metabolic Process
Protein Metabolic Process
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Neurotrophin TRKA Receptor Binding
Phosphoserine Residue Binding
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Response To Stress
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Cell Population Proliferation
Cell Activation
Protein Tyrosine Kinase Activity
Regulation Of Intracellular Transport
Phosphatidylinositol 3-kinase Complex
Leukocyte Activation
Lymphocyte Activation
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphatase Binding
Regulation Of Leukocyte Cell-cell Adhesion
Intracellular Signaling Cassette
Regulation Of T Cell Activation
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