GHR and NCOA6

Number of citations of the paper that reports this interaction (PMID 10567404)
54

Data Source:
HPRD (in vitro)

		GHR	NCOA6
Gene Name		growth hormone receptor	nuclear receptor coactivator 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex	Nucleus Nucleoplasm Transcription Factor Complex Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	DNA Replication DNA Repair DNA Recombination DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Myeloid Cell Differentiation Intracellular Estrogen Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs		Somatropin recombinant Pegvisomant
Diseases
GWAS		Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2	64 interactors: AR ASCC1 ATF2 BCL3 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 HIST2H3C HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOA1 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335
Entrez ID		2690	23054
HPRD ID		02971	05599
Ensembl ID		ENSG00000112964	ENSG00000198646
Uniprot IDs		P10912	F6M2K2 Q14686
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway	Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Gene Expression Steroid Hormone Mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Lipid Response To Hormone Cellular Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Difference) ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining	candidate cardiomyopathy coactivator coding contractile dcm defects delta depletion dilated dilation dysfunction embryonic germline heart humans idcm idiopathic left lethality malfunction nonsynonymous peroxisome ppardelta progressive proliferator sequencing unclear ventricular
Tagcloud (Intersection) ?