SOCS3 and JAK2

  • Number of citations of the paper that reports this interaction (PMID 10421843)
  • 75
  • Data Source:
  • HPRD (in vitro, two hybrid, in vivo)

SOCS3

JAK2

Gene Name suppressor of cytokine signaling 3 Janus kinase 2
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions 48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1 94 interactors: ABL1 AGTR1 ASS1 BCR BRCA1 CCR5 CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I HES1 HES5 HIST3H3 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1
Entrez ID 9021 3717
HPRD ID 05006 00993
Ensembl ID ENSG00000184557 ENSG00000096968
Uniprot IDs O14543 Q6FI39 O60674
PDB IDs 2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
activates  activator  ameliorate  attenuate  autoimmune  cd25lowcd44lowcd62lhigh  cd4  coculture  enhance  fate  h3k27me3  h3k4me3  immunomodulatory  immunoregulatory  inhibit  interferon  leading  manifestations  mesenchymal  msc  mscs  promoters  reciprocal  rorgammat  stat1  stat3  suppressors  th17  transducer 
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
Tagcloud (Difference) ?
activates  activator  ameliorate  attenuate  autoimmune  cd25lowcd44lowcd62lhigh  cd4  coculture  enhance  fate  h3k27me3  h3k4me3  immunomodulatory  immunoregulatory  inhibit  interferon  leading  manifestations  mesenchymal  msc  mscs  promoters  reciprocal  rorgammat  stat1  stat3  suppressors  th17  transducer 
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
Tagcloud (Intersection) ?