SOCS3 and PRLR

Number of citations of the paper that reports this interaction (PubMedID 11713228)
0

Data Source:
HPRD (in vivo)

		SOCS3	PRLR
Description		suppressor of cytokine signaling 3	prolactin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Side Of Plasma Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endosome Lumen Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Protein Kinase Binding Cytokine Binding Metal Ion Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Response To Bacterium Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Positive Regulation Of B Cell Proliferation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Mammary Gland Epithelium Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Lonapegsomatropin
Diseases
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Chronotype ( 30696823) DHEAS levels ( 34748635) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		9021	5618
HPRD ID		05006	01457
Ensembl ID		ENSG00000184557	ENSG00000113494
Uniprot IDs		O14543 Q6FI39	P16471
PDB IDs			1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation	Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Protein Modification Process Regulation Of Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Positive Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphorylation-dependent Protein Binding Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Prolactin Receptor Binding Positive Regulation Of Immune System Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Signal Transduction Cytokine Receptor Binding Developmental Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Sequestering Activity
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