SOCS3 and TFR2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SOCS3	TFR2
Name		suppressor of cytokine signaling 3	transferrin receptor 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Side Of Plasma Membrane	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding	Transferrin Receptor Activity Protein Binding Co-receptor Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor	Iron Ion Transport Intracellular Iron Ion Homeostasis Receptor-mediated Endocytosis Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Transferrin endocytosis and recycling
Drugs		None	Ferrous sulfate anhydrous Ferric derisomaltose
Diseases		None	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Asthma ( 32296059 ) Blood trace element (Se levels) ( 23720494 ) Creatine kinase levels ( 29403010 )	Apolipoprotein B levels ( 32203549 ) Eosinophil count ( 32888494 ) Hematocrit ( 19862010 28017375 32888494 27863252 ) Hematological parameters ( 19820697 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 28017375 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Iron status biomarkers ( 21208937 ) Iron status biomarkers (iron levels) ( 25352340 33536631 ) Iron status biomarkers (transferrin saturation) ( 33536631 25352340 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 28017375 32888494 29403010 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 29403010 27863252 ) Mean corpuscular volume ( 19862010 32888494 27863252 28017375 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Red blood cell count ( 28017375 28453575 29403010 27863252 32888494 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte fraction of red cells ( 32888494 27863252 )
Interacting Genes		66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	7 interacting genes: CFTR DCLRE1B HFE OLFM4 SEC22A SOCS3 TF
Entrez ID		9021	7036
HPRD ID		05006	05282
Ensembl ID		ENSG00000184557	ENSG00000106327
Uniprot IDs		O14543 Q6FI39	Q9UP52
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation	Multicellular Organismal-level Chemical Homeostasis HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Basal Part Of Cell Recycling Endosome Multicellular Organismal-level Iron Ion Homeostasis Response To Iron Ion Perinuclear Region Of Cytoplasm Iron Ion Transport Positive Regulation Of Receptor-mediated Endocytosis Early Endosome Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Intracellular Iron Ion Homeostasis Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Anion Channel Activity Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Response To Antipsychotic Drug Telomeric Loop Formation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Multicellular Organismal-level Homeostasis Positive Regulation Of Monoatomic Anion Transport Regulation Of Receptor-mediated Endocytosis Response To Iron Ion Starvation Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Intracellular Chemical Homeostasis Positive Regulation Of Enamel Mineralization Regulation Of Vesicle-mediated Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-lactamase Activity 5'-3' DNA Exonuclease Activity Telomeric 3' Overhang Formation Positive Regulation Of Hormone Secretion Transepithelial Water Transport Positive Regulation Of Endocytosis Cellular Homeostasis Positive Regulation Of Tooth Mineralization Regulation Of Iron Ion Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Metal Ion Bicarbonate Transmembrane Transporter Activity