SOCS3 and TFR2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS3	TFR2
Gene Name		suppressor of cytokine signaling 3	transferrin receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Transferrin Receptor Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis
Pathways		Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)	Hematocrit ( 19862010) Hematological parameters ( 19820697) Iron levels ( 21208937) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1	3 interactors: HFE SOCS3 TF
Entrez ID		9021	7036
HPRD ID		05006	05282
Ensembl ID		ENSG00000184557	ENSG00000106327
Uniprot IDs		O14543 Q6FI39	Q9UP52
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process	Iron Ion Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis Transition Metal Ion Homeostasis Cellular Response To Iron Ion Starvation Multicellular Organismal Homeostasis Spongiotrophoblast Differentiation Iron Ion Import Into Cell Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Cellular Chemical Homeostasis Ion Homeostasis Iron Ion Import Spongiotrophoblast Layer Development Multicellular Organismal Iron Ion Homeostasis Cellular Homeostasis Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of JAK-STAT Cascade Labyrinthine Layer Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Stress Cellular Response To Growth Hormone Stimulus Embryonic Placenta Morphogenesis Metal Ion Transport Chemical Homeostasis Regulation Of Immune Response Transferrin Transport Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Hormone Biosynthetic Process JAK-STAT Cascade Cation Transport Labyrinthine Layer Development Retina Homeostasis Regulation Of Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Platelet Degranulation Reproductive Process Homeostatic Process Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc
Tagcloud (Difference) ?		activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer	arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc
Tagcloud (Intersection) ?