GHR and PTPN3

Number of citations of the paper that reports this interaction (PMID 12907755)
14

Data Source:
BioGRID (pull down, far western blotting)

		GHR	PTPN3
Gene Name		growth hormone receptor	protein tyrosine phosphatase, non-receptor type 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex	Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatropin recombinant Pegvisomant
Diseases
GWAS		Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2	14 interactors: ADAM17 AKR1C1 CD247 DIP2A GHR LMO1 NXT2 VCP WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		2690	5774
HPRD ID		02971	06767
Ensembl ID		ENSG00000112964	ENSG00000070159
Uniprot IDs		P10912	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR	2B49
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Cellular Response To Hormone Stimulus Regulation Of Mitochondrion Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Peptide Hormone Growth Hormone Receptor Signaling Pathway Regulation Of Cell Death Cellular Response To Organonitrogen Compound Cellular Response To Growth Hormone Stimulus Response To Hormone Response To Peptide Apoptotic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Cell Death Positive Regulation Of Apoptotic Signaling Pathway Death Response To Growth Hormone Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Cell Death Positive Regulation Of Intracellular Transport Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Protein Transport Signaling T Cell Differentiation In Thymus Regulation Of Kinase Activity Cell Communication Establishment Of Protein Localization Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Beta Selection Positive Regulation Of Protein Modification Process
Tagcloud ?		becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining	adaptor advance border cascades dephosphorylation doi dptpmeg drosophila egfr endocytosis eps15 ferm homolog impairs lysosomal morphogenesis onc oncogene online pdz publication raft scaffolding september suppress trafficking tumorigenicity wing xenograft
Tagcloud (Difference) ?		becomes ceptor continuous continuously cwsv eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining	adaptor advance border cascades doi dptpmeg drosophila egfr endocytosis eps15 ferm homolog impairs lysosomal morphogenesis onc oncogene online pdz publication raft scaffolding september suppress trafficking tumorigenicity wing xenograft
Tagcloud (Intersection) ?		dephosphorylation