SOCS3 and CSF1R

Number of citations of the paper that reports this interaction (PubMedID 12133942)
0

Data Source:
HPRD (in vivo)

		SOCS3	CSF1R
Description		suppressor of cytokine signaling 3	colony stimulating factor 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Side Of Plasma Membrane	Nucleoplasm Plasma Membrane Cell Surface Membrane Receptor Complex CSF1-CSF1R Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Phosphatase Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor	Positive Regulation Of Protein Phosphorylation Immune System Process Myeloid Leukocyte Differentiation Response To Ischemia Response To Stress Inflammatory Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Anatomical Structure Morphogenesis Positive Regulation Of Macrophage Chemotaxis Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Olfactory Bulb Development Forebrain Neuron Differentiation Regulation Of Cell Morphogenesis Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Chemokine Production Regulation Of Actin Cytoskeleton Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Host-mediated Activation Of Viral Process Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Protein Autophosphorylation Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Microglial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Macrophage Proliferation Regulation Of Macrophage Migration Positive Regulation Of Cell Motility
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Other interleukin signaling Transcriptional Regulation by VENTX Signaling by CSF1 (M-CSF) in myeloid cells
Drugs			Imatinib Sunitinib Linifanib 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib
Diseases			Choriocarcinoma
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin levels ( 33491795) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1
Entrez ID		9021	1436
HPRD ID		05006	01269
Ensembl ID		ENSG00000184557	ENSG00000182578
Uniprot IDs		O14543 Q6FI39	P07333
PDB IDs			2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33 6T2W 6WXJ 7MFC 8CGC 8JOT 8W1L
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction SH3 Domain Binding Fc Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Immune System Process Immune Effector Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Myeloid Leukocyte Differentiation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Activation Signal Transduction Immune System Process Mononuclear Cell Differentiation Regulation Of Immune Response Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway T Cell Costimulation Leukocyte Activation Leukocyte Differentiation Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Insulin Receptor Substrate Binding Myeloid Cell Differentiation Activation Of Immune Response Regulation Of Actin Filament Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Defense Response Lymphocyte Activation T Cell Activation Response To Insulin Regulation Of Developmental Process
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