DPM1 and MTNR1A

Number of citations of the paper that reports this interaction (PubMedID 17215244)
0

Data Source:
HPRD (in vitro)

		DPM1	MTNR1A
Description		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	melatonin receptor 1A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding D-mannose Binding Transferase Activity Glycosyltransferase Activity Alcohol Binding Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine GDP-mannose Metabolic Process Protein O-linked Glycosylation Via Mannose Response To Oxygen Levels Dolichol Phosphate Mannose Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)
Interacting Genes		9 interacting genes: DPM2 DPM3 FILNC1 MEOX2 MTNR1A PTEN TDO2 TIAM1 ZBTB16	160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460
Entrez ID		8813	4543
HPRD ID		04613	02812
Ensembl ID		ENSG00000000419	ENSG00000168412
Uniprot IDs		A0A0S2Z4Y5 H0Y368 O60762 Q5QPK2	P48039
PDB IDs			6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Isoprenoid Biosynthetic Process Reproductive Behavior Phospholipid Biosynthetic Process Embryonic Pattern Specification Negative Regulation Of Synaptic Vesicle Clustering Phospholipid Metabolic Process L-tryptophan Catabolic Process To Acetyl-CoA Glycolipid Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Adaptor Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Organophosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Response To Nitroglycerin Type 2 Angiotensin Receptor Binding Glycolipid Metabolic Process Terpenoid Metabolic Process Enzyme Activator Activity PML Body Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Regulation Of Epithelial To Mesenchymal Transition Rhythmic Synaptic Transmission Tryptophan 2,3-dioxygenase Activity Male Germ-line Stem Cell Asymmetric Division Isoprenoid Metabolic Process Melatonin Receptor Activity Circadian Rhythm Organophosphate Biosynthetic Process Lipid Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Metabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Somite Specification Regulation Of Axonogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Central Nervous System Development Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity L-tryptophan Catabolic Process To Kynurenine Protein Glycosylation Macromolecule Glycosylation Glycosylation Regulation Of Synaptic Vesicle Clustering Regulation Of NK T Cell Differentiation Negative Regulation Of Peptidyl-serine Phosphorylation	Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity
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