DPM1 and DPM3

Number of citations: 31 (PubMedID 10835346)
Data Source: HPRD (in vivo)

		DPM1	DPM3
Name		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding D-mannose Binding Transferase Activity Glycosyltransferase Activity Alcohol Binding Metal Ion Binding	Protein Binding Enzyme Activator Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine GDP-mannose Metabolic Process Protein O-linked Glycosylation Via Mannose Response To Oxygen Levels Dolichol Phosphate Mannose Biosynthetic Process	Protein Glycosylation Protein O-linked Glycosylation Via Mannose Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Diseases		Congenital disorders of glycosylation (CDG) type I	None
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Inflammatory bowel disease ( 28067908 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 ) Prostate cancer ( 23535732 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urate levels ( 31578528 ) Urinary albumin-to-creatinine ratio ( 31630189 )
Interacting Genes		9 interacting genes: DPM2 DPM3 FILNC1 MEOX2 MTNR1A PTEN TDO2 TIAM1 ZBTB16	6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147
Entrez ID		8813	54344
HPRD ID		04613	16179
Ensembl ID		ENSG00000000419	ENSG00000179085
Uniprot IDs		A0A0S2Z4Y5 H0Y368 O60762 Q5QPK2	A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Isoprenoid Biosynthetic Process Reproductive Behavior Phospholipid Biosynthetic Process Embryonic Pattern Specification Negative Regulation Of Synaptic Vesicle Clustering Phospholipid Metabolic Process L-tryptophan Catabolic Process To Acetyl-CoA Glycolipid Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Adaptor Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Organophosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Response To Nitroglycerin Type 2 Angiotensin Receptor Binding Glycolipid Metabolic Process Terpenoid Metabolic Process Enzyme Activator Activity PML Body Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Regulation Of Epithelial To Mesenchymal Transition Rhythmic Synaptic Transmission Tryptophan 2,3-dioxygenase Activity Male Germ-line Stem Cell Asymmetric Division Isoprenoid Metabolic Process Melatonin Receptor Activity Circadian Rhythm Organophosphate Biosynthetic Process Lipid Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Metabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Somite Specification Regulation Of Axonogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Central Nervous System Development Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity L-tryptophan Catabolic Process To Kynurenine Protein Glycosylation Macromolecule Glycosylation Glycosylation Regulation Of Synaptic Vesicle Clustering Regulation Of NK T Cell Differentiation Negative Regulation Of Peptidyl-serine Phosphorylation	Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Endoplasmic Reticulum Membrane Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Metabolic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Dolichyl-phosphate Beta-D-mannosyltransferase Activity Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Phosphatidylinositol Biosynthetic Process Alcohol Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Metabolic Process Protein Glycosylation Macromolecule Glycosylation Protein Localization To Nuclear Inner Membrane Positive Regulation Of Extracellular Matrix Constituent Secretion Glycosylation Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Regulation Of Extracellular Matrix Constituent Secretion Glycerophospholipid Metabolic Process Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Type B Pancreatic Cell Differentiation Protein O-linked Glycosylation Via Mannose GDP-mannose Metabolic Process Golgi Vesicle Transport Negative Regulation Of Autophagosome Assembly Glycerolipid Metabolic Process Protein Localization To Nuclear Envelope Phospholipid Metabolic Process Enteroendocrine Cell Differentiation Insulin Metabolic Process Establishment Of Protein Localization Regulation Of Fibroblast Apoptotic Process Protein N-linked Glycosylation Via Asparagine D-mannose Binding Positive Regulation Of Extracellular Matrix Organization Enzyme Regulator Activity Carbohydrate Derivative Biosynthetic Process Protein Insertion Into ER Membrane Cellular Localization Lipid Biosynthetic Process