DPM1 and TIAM1

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		DPM1	TIAM1
Name		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	TIAM Rac1 associated GEF 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding D-mannose Binding Transferase Activity Glycosyltransferase Activity Alcohol Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine GDP-mannose Metabolic Process Protein O-linked Glycosylation Via Mannose Response To Oxygen Levels Dolichol Phosphate Mannose Biosynthetic Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG	NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5
Diseases		Congenital disorders of glycosylation (CDG) type I	None
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 )	Cervical high-risk human papilloma virus infection ( 33225922 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Renal sinus fat ( 22044751 ) Waist circumference ( 28552196 )
Novel Interactors		None recorded	1 novel interactors: GART
Interacting Genes		9 interacting genes: DPM2 DPM3 FILNC1 MEOX2 MTNR1A PTEN TDO2 TIAM1 ZBTB16	86 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793
Entrez ID		8813	7074
HPRD ID		04613	02820
Ensembl ID		ENSG00000000419	ENSG00000156299
Uniprot IDs		A0A0S2Z4Y5 H0Y368 O60762 Q5QPK2	A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009
PDB IDs		Not available	2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR
GO Terms Enriched among Interactors		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Isoprenoid Biosynthetic Process Reproductive Behavior Phospholipid Biosynthetic Process Embryonic Pattern Specification Negative Regulation Of Synaptic Vesicle Clustering Phospholipid Metabolic Process L-tryptophan Catabolic Process To Acetyl-CoA Glycolipid Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Adaptor Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Organophosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Response To Nitroglycerin Type 2 Angiotensin Receptor Binding Glycolipid Metabolic Process Terpenoid Metabolic Process Enzyme Activator Activity PML Body Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Regulation Of Epithelial To Mesenchymal Transition Rhythmic Synaptic Transmission Tryptophan 2,3-dioxygenase Activity Male Germ-line Stem Cell Asymmetric Division Isoprenoid Metabolic Process Melatonin Receptor Activity Circadian Rhythm Organophosphate Biosynthetic Process Lipid Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Metabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Somite Specification Regulation Of Axonogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Central Nervous System Development Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity L-tryptophan Catabolic Process To Kynurenine Protein Glycosylation Macromolecule Glycosylation Glycosylation Regulation Of Synaptic Vesicle Clustering Regulation Of NK T Cell Differentiation Negative Regulation Of Peptidyl-serine Phosphorylation	Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly