DPM1 and TDO2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		DPM1	TDO2
Description		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	tryptophan 2,3-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Cytosol
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding D-mannose Binding Transferase Activity Glycosyltransferase Activity Alcohol Binding Metal Ion Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Oxidoreductase Activity Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine GDP-mannose Metabolic Process Protein O-linked Glycosylation Via Mannose Response To Oxygen Levels Dolichol Phosphate Mannose Biosynthetic Process	L-tryptophan Metabolic Process L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine L-tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG	Tryptophan catabolism
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		9 interacting genes: DPM2 DPM3 FILNC1 MEOX2 MTNR1A PTEN TDO2 TIAM1 ZBTB16	20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26
Entrez ID		8813	6999
HPRD ID		04613	01847
Ensembl ID		ENSG00000000419	ENSG00000151790
Uniprot IDs		A0A0S2Z4Y5 H0Y368 O60762 Q5QPK2	P48775
PDB IDs			4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6UD5 6VBN 7LU7 7UI3 8QV7 8R5Q 8R5R 8VTQ 8VUG 8VZV 8W1H 8W2K 9AT2 9B17 9B1Q 9EZJ
Enriched GO Terms of Interacting Partners?		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Isoprenoid Biosynthetic Process Reproductive Behavior Phospholipid Biosynthetic Process Embryonic Pattern Specification Negative Regulation Of Synaptic Vesicle Clustering Phospholipid Metabolic Process L-tryptophan Catabolic Process To Acetyl-CoA Glycolipid Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Adaptor Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Organophosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Response To Nitroglycerin Type 2 Angiotensin Receptor Binding Glycolipid Metabolic Process Terpenoid Metabolic Process Enzyme Activator Activity PML Body Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Regulation Of Epithelial To Mesenchymal Transition Rhythmic Synaptic Transmission Tryptophan 2,3-dioxygenase Activity Male Germ-line Stem Cell Asymmetric Division Isoprenoid Metabolic Process Melatonin Receptor Activity Circadian Rhythm Organophosphate Biosynthetic Process Lipid Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Metabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Somite Specification Regulation Of Axonogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Central Nervous System Development Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity L-tryptophan Catabolic Process To Kynurenine Protein Glycosylation Macromolecule Glycosylation Glycosylation Regulation Of Synaptic Vesicle Clustering Regulation Of NK T Cell Differentiation Negative Regulation Of Peptidyl-serine Phosphorylation
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