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DPM1
Gene Name
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Dolichol-phosphate-mannose Synthase Complex
Molecular Function
Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity
Dolichyl-phosphate Beta-D-mannosyltransferase Activity
Protein Binding
Mannose Binding
Alcohol Binding
Biological Process
Dolichol-linked Oligosaccharide Biosynthetic Process
C-terminal Protein Lipidation
GPI Anchor Biosynthetic Process
Protein N-linked Glycosylation Via Asparagine
Dolichol Metabolic Process
GDP-mannose Metabolic Process
Protein Mannosylation
Protein O-linked Mannosylation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Synthesis of dolichyl-phosphate mannose
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Post-translational modification: synthesis of GPI-anchored proteins
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Synthesis of dolichyl-phosphate mannose
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions
5 interactors:
DPM2
DPM3
MTNR1A
TDO2
ZBTB16
Entrez ID
8813
HPRD ID
04613
Ensembl ID
ENSG00000000419
Uniprot IDs
O60762
Q5QPK2
PDB IDs
Enriched GO Terms of Interacting Partners
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Protein O-linked Mannosylation
Protein Mannosylation
C-terminal Protein Lipidation
Mannosylation
Dolichol-linked Oligosaccharide Biosynthetic Process
GPI Anchor Biosynthetic Process
GPI Anchor Metabolic Process
Glycolipid Biosynthetic Process
Protein O-linked Glycosylation
Protein N-linked Glycosylation Via Asparagine
Protein Lipidation
Lipoprotein Biosynthetic Process
Protein N-linked Glycosylation
Phosphatidylinositol Biosynthetic Process
Glycolipid Metabolic Process
Regulation Of Protein Stability
Tryptophan Catabolic Process To Acetyl-CoA
Lipoprotein Metabolic Process
Glycerophospholipid Biosynthetic Process
Post-translational Protein Modification
Dolichol Metabolic Process
Phosphatidylinositol Metabolic Process
Membrane Lipid Metabolic Process
Positive Regulation Of NK T Cell Differentiation
Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan
Phospholipid Biosynthetic Process
Male Germ-line Stem Cell Asymmetric Division
Glycerophospholipid Metabolic Process
Macromolecule Glycosylation
Protein Glycosylation
Tryptophan Catabolic Process To Kynurenine
Glycosylation
Kynurenine Metabolic Process
Glycerolipid Metabolic Process
Phospholipid Metabolic Process
Glycoprotein Biosynthetic Process
Preassembly Of GPI Anchor In ER Membrane
Glycoprotein Metabolic Process
Tryptophan Catabolic Process
Posttranscriptional Regulation Of Gene Expression
Positive Regulation Of CGMP Biosynthetic Process
Tryptophan Metabolic Process
Positive Regulation Of CGMP Metabolic Process
Acetyl-CoA Metabolic Process
Regulation Of CGMP Biosynthetic Process
Lipid Biosynthetic Process
Positive Regulation Of Chondrocyte Differentiation
Regulation Of CGMP Metabolic Process
Mating Behavior
Stem Cell Division
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