DPM1 and DPM2

Number of citations: 31 (PubMedID 10835346)
Data Source: HPRD (in vivo)

		DPM1	DPM2
Name		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding D-mannose Binding Transferase Activity Glycosyltransferase Activity Alcohol Binding Metal Ion Binding	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine GDP-mannose Metabolic Process Protein O-linked Glycosylation Via Mannose Response To Oxygen Levels Dolichol Phosphate Mannose Biosynthetic Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Diseases		Congenital disorders of glycosylation (CDG) type I	None
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 )	Body mass index ( 26426971 ) Glaucoma (primary angle closure) ( 27064256 )
Interacting Genes		9 interacting genes: DPM2 DPM3 FILNC1 MEOX2 MTNR1A PTEN TDO2 TIAM1 ZBTB16	7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1
Entrez ID		8813	8818
HPRD ID		04613	16028
Ensembl ID		ENSG00000000419	ENSG00000136908
Uniprot IDs		A0A0S2Z4Y5 H0Y368 O60762 Q5QPK2	O94777
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Isoprenoid Biosynthetic Process Reproductive Behavior Phospholipid Biosynthetic Process Embryonic Pattern Specification Negative Regulation Of Synaptic Vesicle Clustering Phospholipid Metabolic Process L-tryptophan Catabolic Process To Acetyl-CoA Glycolipid Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Adaptor Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Organophosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Response To Nitroglycerin Type 2 Angiotensin Receptor Binding Glycolipid Metabolic Process Terpenoid Metabolic Process Enzyme Activator Activity PML Body Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Regulation Of Epithelial To Mesenchymal Transition Rhythmic Synaptic Transmission Tryptophan 2,3-dioxygenase Activity Male Germ-line Stem Cell Asymmetric Division Isoprenoid Metabolic Process Melatonin Receptor Activity Circadian Rhythm Organophosphate Biosynthetic Process Lipid Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Metabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Somite Specification Regulation Of Axonogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Central Nervous System Development Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity L-tryptophan Catabolic Process To Kynurenine Protein Glycosylation Macromolecule Glycosylation Glycosylation Regulation Of Synaptic Vesicle Clustering Regulation Of NK T Cell Differentiation Negative Regulation Of Peptidyl-serine Phosphorylation	Glycolipid Biosynthetic Process Glycolipid Metabolic Process GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein O-linked Glycosylation Via Mannose Endoplasmic Reticulum Membrane Phosphatidylinositol Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Glycerophospholipid Biosynthetic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum Glycerophospholipid Metabolic Process Carbohydrate Derivative Metabolic Process Glycerolipid Metabolic Process Organophosphate Metabolic Process MHC Class II Protein Complex Assembly Dolichyl-phosphate Beta-D-mannosyltransferase Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Lipid Metabolic Process Terpenoid Metabolic Process Pyrimidine Nucleoside Transmembrane Transporter Activity Amine Transmembrane Transporter Activity Isoprenoid Metabolic Process Alcohol Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Protein O-linked Glycosylation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phosphate-containing Compound Metabolic Process Histamine Uptake Putrescine Transmembrane Transporter Activity Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane