DYRK4 and FBXO25

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		DYRK4	FBXO25
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	F-box protein 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Peptidyl-tyrosine Phosphorylation	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CUL3 DYRK2 FBXO25 MID1 NEDD4 PPP1CC	80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		8798	26260
HPRD ID		10926	16439
Ensembl ID		ENSG00000010219	ENSG00000147364
Uniprot IDs		B4E1A4 D3JEN2 Q9NR20	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Monoubiquitination Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Protein Ubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation Catabolic Process Depurination Trophectodermal Cellular Morphogenesis Protein Polyubiquitination Cellular Macromolecule Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Protein Catabolic Process Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage DNA Dealkylation Involved In DNA Repair Negative Regulation Of Signal Transduction Base-excision Repair, AP Site Formation Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Localization To Microtubule Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Signal Transduction Signal Transduction Response To Light Stimulus Protein Targeting To Lysosome Apoptotic Signaling Pathway Embryonic Cleavage Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Signaling Protein Localization To Lysosome Stress Fiber Assembly Signaling Regulation Of Protein Catabolic Process Negative Regulation Of Transport Cell Communication Positive Regulation Of Chromosome Segregation Deoxyribose Phosphate Catabolic Process Cellular Response To Stress	Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process
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