DYRK4 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		DYRK4	FBXO25
Description		dual specificity tyrosine phosphorylation regulated kinase 4	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process		Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		6 interacting genes: CUL3 DYRK2 FBXO25 MID1 NEDD4 PPP1CC	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		8798	26260
HPRD ID		10926	16439
Ensembl ID		ENSG00000010219	ENSG00000147364
Uniprot IDs		A0A0A0MTH5 B4E1A4 D3JEN2 Q9NR20	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Complex Protein Modification Process Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Cytoskeleton Regulation Of Nucleocytoplasmic Transport Channel Inhibitor Activity Glutamatergic Synapse Protein Metabolic Process Trophectodermal Cellular Morphogenesis Liver Morphogenesis Protein Ubiquitination Phosphothreonine Residue Binding Regulation Protein Catabolic Process At Postsynapse Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Sodium Ion Transport Protein-containing Complex Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Intrinsic Apoptotic Signaling Pathway POZ Domain Binding Polar Microtubule Post-translational Protein Modification Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Intracellular Signal Transduction Protein Domain Specific Binding PTW/PP1 Phosphatase Complex Nuclear Protein Quality Control By The Ubiquitin-proteasome System Spindle Sodium Channel Inhibitor Activity Postsynapse Ubiquitin Ligase Complex Scaffold Activity Embryonic Cleavage	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
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