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DYRK4 and NEDD4
Number of citations of the paper that reports this interaction (PMID
19953087
)
25
Data Source:
BioGRID
(pull down)
DYRK4
NEDD4
Gene Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Intracellular Membrane-bounded Organelle
Ubiquitin Ligase Complex
Chromatin
Nucleus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Apicolateral Plasma Membrane
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Binding
Ligase Activity
Sodium Channel Inhibitor Activity
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ubiquitin Binding
Phosphoserine Binding
Phosphothreonine Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Biological Process
Peptidyl-tyrosine Phosphorylation
Adaptive Immune Response
Outflow Tract Morphogenesis
Endocardial Cushion Development
Protein Monoubiquitination
Protein Targeting To Lysosome
Lysosomal Transport
Neuromuscular Junction Development
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Protein Ubiquitination
Transmission Of Virus
Cytokine-mediated Signaling Pathway
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
Regulation Of Ion Transmembrane Transport
T Cell Activation
Regulation Of Membrane Potential
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Glucocorticoid Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Development Involved In Symbiotic Interaction
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Nucleocytoplasmic Transport
Blood Vessel Morphogenesis
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways
Downregulation of ERBB4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
ISG15 antiviral mechanism
Interferon Signaling
Cytokine Signaling in Immune system
Class I MHC mediated antigen processing & presentation
Signaling by ERBB4
Antiviral mechanism by IFN-stimulated genes
Adaptive Immune System
Drugs
Diseases
GWAS
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
20062064
)
Keloid (
20711176
)
Protein-Protein Interactions
6 interactors:
CUL3
DYRK2
FBXO25
MID1
NEDD4
PPP1CC
215 interactors:
ABL1
ABL2
ADRB2
AKT3
AMOT
AMOTL1
AMPD2
ANKRD13D
ANXA13
AP1G2
ARID1A
ARRDC1
ARRDC3
ASPSCR1
AURKC
BAIAP2
BECN1
BMPR1A
BRCA2
C11orf63
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CUEDC1
DAZAP2
DCUN1D1
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EPHA5
EPRS
EPS15
ERBB3
ERBB4
ERMN
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FYN
GBA
GRB10
GRIN2A
GRK4
GRK7
HGS
HMCES
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
IGF1R
IRS1
JUN
KCNAB1
KCNAB2
KIAA1598
KIFC3
LAPTM5
LATS1
LITAF
LUC7L2
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MTMR4
MYCN
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NSRP1
NTRK1
NUDT21
PARP16
PDGFRB
PKN2
PLK1
PLK2
PMEPA1
POLR2A
POLR2B
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRRG1
PRRG2
PSMD4
PTEN
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RFT1
RNF11
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUVBL1
SAAL1
SAMSN1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPT9
SFTPC
SGK1
SGK2
SH3KBP1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
SULF1
SYK
SYT1
TAF1B
TBC1D7
TBK1
TCEANC
TCP11L1
TEAD2
THRAP3
TNIK
TOM1
TOM1L2
TP73
TRIM44
TRIM52
TRPV6
TSTA3
TTYH2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2M
UBOX5
URI1
WBP1
WBP2
WEE1
WIBG
YES1
YOD1
Entrez ID
8798
4734
HPRD ID
10926
03786
Ensembl ID
ENSG00000010219
ENSG00000069869
Uniprot IDs
B4E1A4
D3JEN2
Q9NR20
P46934
PDB IDs
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
Enriched GO Terms of Interacting Partners
?
Protein Monoubiquitination
Cell Surface Receptor Signaling Pathway
Cellular Protein Modification Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Protein Ubiquitination
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Protein Modification By Small Protein Conjugation
Catabolic Process
Depurination
Trophectodermal Cellular Morphogenesis
Protein Polyubiquitination
Cellular Macromolecule Catabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Nucleocytoplasmic Transport
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Positive Regulation Of Protein Catabolic Process
Progesterone Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
DNA Dealkylation Involved In DNA Repair
Negative Regulation Of Signal Transduction
Base-excision Repair, AP Site Formation
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Protein Localization To Microtubule
Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Signaling
Negative Regulation Of NFAT Protein Import Into Nucleus
Regulation Of Signal Transduction
Signal Transduction
Response To Light Stimulus
Protein Targeting To Lysosome
Apoptotic Signaling Pathway
Embryonic Cleavage
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Protein Metabolic Process
Positive Regulation Of Glycogen Biosynthetic Process
Regulation Of Signaling
Protein Localization To Lysosome
Stress Fiber Assembly
Signaling
Regulation Of Protein Catabolic Process
Negative Regulation Of Transport
Cell Communication
Positive Regulation Of Chromosome Segregation
Deoxyribose Phosphate Catabolic Process
Cellular Response To Stress
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Protein Metabolic Process
Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Protein Autophosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Phosphorylation
Response To Growth Factor
Response To Stimulus
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Signaling
Cell Communication
Cellular Protein Modification Process
Regulation Of Phosphorylation
Signal Transduction
Regulation Of Protein Phosphorylation
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Phosphorylation
Phosphate-containing Compound Metabolic Process
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Kinase Activity
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of Cell Death
Regulation Of Metabolic Process
Cellular Protein Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Catalytic Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Catalytic Activity
Regulation Of Cellular Component Organization
Regulation Of Cellular Process
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Peptidyl-tyrosine Phosphorylation
ERBB Signaling Pathway
Cellular Metabolic Process
Positive Regulation Of Kinase Activity
Peptidyl-amino Acid Modification
Tagcloud
?
accepted
colocalization
colocalized
conjugating
cooperation
cysteine
cytoplasm
deleted
e2
e6ap
enabled
hect
ligase
neural
neurites
perinuclear
periphery
simultaneous
specificities
transfer
ubc4
ubch5b
ubch5c
ubch6
ubch7
ubiquitin
ubiquitination
ubiquitins
ww
Tagcloud (Difference)
?
accepted
colocalization
colocalized
conjugating
cooperation
cysteine
cytoplasm
deleted
e2
e6ap
enabled
hect
ligase
neural
neurites
perinuclear
periphery
simultaneous
specificities
transfer
ubc4
ubch5b
ubch5c
ubch6
ubch7
ubiquitin
ubiquitination
ubiquitins
ww
Tagcloud (Intersection)
?