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DYRK4 and DYRK2
Number of citations of the paper that reports this interaction (PMID
23602568
)
8
Data Source:
BioGRID
(affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)
DYRK4
DYRK2
Gene Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Intracellular Membrane-bounded Organelle
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Ribonucleoprotein Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Manganese Ion Binding
Ubiquitin Binding
Biological Process
Peptidyl-tyrosine Phosphorylation
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Smoothened Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of NFAT Protein Import Into Nucleus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
CUL3
DYRK2
FBXO25
MID1
NEDD4
PPP1CC
20 interactors:
APP
ATM
DDB1
DYRK4
HIST2H2BE
HIST3H3
IKZF1
KATNA1
KXD1
LZTS2
MDM2
NR1I2
RAD54B
SIAH2
SP100
TERT
UBC
UBR5
WDR62
ZBTB9
Entrez ID
8798
8445
HPRD ID
10926
04606
Ensembl ID
ENSG00000010219
Uniprot IDs
B4E1A4
D3JEN2
Q9NR20
Q92630
PDB IDs
3K2L
3KVW
4AZF
Enriched GO Terms of Interacting Partners
?
Protein Monoubiquitination
Cell Surface Receptor Signaling Pathway
Cellular Protein Modification Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Protein Ubiquitination
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Protein Modification By Small Protein Conjugation
Catabolic Process
Depurination
Trophectodermal Cellular Morphogenesis
Protein Polyubiquitination
Cellular Macromolecule Catabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Nucleocytoplasmic Transport
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Positive Regulation Of Protein Catabolic Process
Progesterone Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
DNA Dealkylation Involved In DNA Repair
Negative Regulation Of Signal Transduction
Base-excision Repair, AP Site Formation
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Protein Localization To Microtubule
Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Signaling
Negative Regulation Of NFAT Protein Import Into Nucleus
Regulation Of Signal Transduction
Signal Transduction
Response To Light Stimulus
Protein Targeting To Lysosome
Apoptotic Signaling Pathway
Embryonic Cleavage
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Protein Metabolic Process
Positive Regulation Of Glycogen Biosynthetic Process
Regulation Of Signaling
Protein Localization To Lysosome
Stress Fiber Assembly
Signaling
Regulation Of Protein Catabolic Process
Negative Regulation Of Transport
Cell Communication
Positive Regulation Of Chromosome Segregation
Deoxyribose Phosphate Catabolic Process
Cellular Response To Stress
Telomere Maintenance
Intracellular Receptor Signaling Pathway
DNA Damage Response, Signal Transduction By P53 Class Mediator
Chromosome Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Signal Transduction In Response To DNA Damage
DNA Metabolic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cellular Metabolic Process
Signal Transduction By P53 Class Mediator
Cellular Response To DNA Damage Stimulus
Regulation Of Wnt Signaling Pathway
Cell Cycle
Protein Catabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Mitotic Cell Cycle
Chromatin Organization
Mitotic G1 DNA Damage Checkpoint
Replicative Senescence
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Cell Cycle Arrest
Microtubule Severing
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Arrest
Mitotic DNA Damage Checkpoint
Proteolysis Involved In Cellular Protein Catabolic Process
Organelle Organization
Positive Regulation Of Cell Cycle
Cellular Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Repair
Chromatin Modification
Protein Modification By Small Protein Conjugation
Tagcloud
?
better
clinicopathological
closely
december
dual
free
grade
histological
hormone
hundred
ihc
immunohistochemical
involvement
january
lymph
metastasis
node
predict
predictive
prognosis
recurrence
seventy
specificity
stage
status
surgery
ten
underwent
Tagcloud (Difference)
?
better
clinicopathological
closely
december
dual
free
grade
histological
hormone
hundred
ihc
immunohistochemical
involvement
january
lymph
metastasis
node
predict
predictive
prognosis
recurrence
seventy
specificity
stage
status
surgery
ten
underwent
Tagcloud (Intersection)
?