TRIM63 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		TRIM63	UCHL5
Description		tripartite motif containing 63	ubiquitin C-terminal hydrolase L5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band Contractile Muscle Fiber	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Titin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Innate Immune Response Negative Regulation Of Glycolytic Process Response To Glucocorticoid Response To Interleukin-1	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Cannabis dependence ( 21668797)
Interacting Genes		331 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DMD DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		84676	51377
HPRD ID		05843	10293
Ensembl ID		ENSG00000158022	ENSG00000116750
Uniprot IDs		Q969Q1	Q5LJA5 Q9Y5K5
PDB IDs		2D8U 3DDT 4M3L	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Protein Binding Sarcomere Organization Protein Modification By Small Protein Conjugation Protein Modification Process Structural Constituent Of Muscle Troponin Complex Nucleus Actomyosin Structure Organization Striated Muscle Contraction Z Disc Cardiac Muscle Contraction Ubiquitin Conjugating Enzyme Activity Protein K48-linked Deubiquitination Ubiquitin Protein Ligase Binding Contractile Muscle Fiber Sarcomere Protein Ubiquitination Troponin T Binding Protein Metabolic Process Myofibril Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Contraction Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Deubiquitinase Activity Proteolysis Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process TORC1 Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process TOR Signaling K48-linked Deubiquitinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Myofibril Assembly Nucleoplasm Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Cytosol Titin Binding	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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