TRIM63 and IRF3

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		TRIM63	IRF3
Description		tripartite motif containing 63	interferon regulatory factor 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band Contractile Muscle Fiber	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Titin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Innate Immune Response Negative Regulation Of Glycolytic Process Response To Glucocorticoid Response To Interleukin-1	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Cell Surface Receptor Signaling Pathway MRNA Transcription Response To Bacterium Regulation Of Gene Expression Programmed Cell Death Signal Transduction Involved In Regulation Of Gene Expression Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death Cellular Response To Virus Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Autoimmune thyroid disease ( 32581359) Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		331 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DMD DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16	35 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE ILF3 IRF5 IRF7 JMJD6 MAPK8 MAVS OGT PEX19 PIAS4 PPIB PRDX1 PSMD14 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26 TRIM55 TRIM63 UFL1
Entrez ID		84676	3661
HPRD ID		05843	04769
Ensembl ID		ENSG00000158022	ENSG00000126456
Uniprot IDs		Q969Q1	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653 Q96GL3
PDB IDs		2D8U 3DDT 4M3L	1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA 7JFL
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Protein Binding Sarcomere Organization Protein Modification By Small Protein Conjugation Protein Modification Process Structural Constituent Of Muscle Troponin Complex Nucleus Actomyosin Structure Organization Striated Muscle Contraction Z Disc Cardiac Muscle Contraction Ubiquitin Conjugating Enzyme Activity Protein K48-linked Deubiquitination Ubiquitin Protein Ligase Binding Contractile Muscle Fiber Sarcomere Protein Ubiquitination Troponin T Binding Protein Metabolic Process Myofibril Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Contraction Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Deubiquitinase Activity Proteolysis Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process TORC1 Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process TOR Signaling K48-linked Deubiquitinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Myofibril Assembly Nucleoplasm Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Cytosol Titin Binding	Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Defense Response To Virus Response To Virus Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-beta Production Immune System Process Regulation Of Type I Interferon Production Response To Other Organism Response To External Biotic Stimulus Innate Immune Response Defense Response Activation Of Immune Response Regulation Of Defense Response Canonical NF-kappaB Signal Transduction Regulation Of Interferon-beta Production Regulation Of Innate Immune Response Positive Regulation Of Defense Response Innate Immune Response-activating Signaling Pathway Defense Response To Symbiont Response To Stress Defense Response To Other Organism Positive Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Immune Response Immune Response Positive Regulation Of Immune System Process Cytoplasm Immune Response-regulating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of Immune System Process Protein Modification Process Regulation Of Primary Metabolic Process Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interferon-alpha Production Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Gene Expression
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