TRIM63 and PDK4

Number of citations of the paper that reports this interaction (PMID 18468620)
16

Data Source:
HPRD (two hybrid)

		TRIM63	PDK4
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	pyruvate dehydrogenase kinase, isozyme 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Glucose Metabolic Process Pyruvate Metabolic Process Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Cellular Metabolic Process Small Molecule Metabolic Process Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	3 interactors: DLAT PDHA1 TRIM63
Entrez ID		84676	5166
HPRD ID		05843	03957
Ensembl ID		ENSG00000158022	ENSG00000004799
Uniprot IDs		B4DN95 Q969Q1	A4D1H4 Q16654
PDB IDs		2D8U 3DDT	2E0A 2ZDX 2ZDY 2ZKJ 3D2R
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Glucose Metabolic Process Cellular Respiration Hexose Metabolic Process Monosaccharide Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Skeletal Muscle Atrophy Striated Muscle Atrophy Acetyl-CoA Biosynthetic Process Muscle Atrophy Generation Of Precursor Metabolites And Energy Skeletal Muscle Adaptation Regulation Of Cellular Ketone Metabolic Process Monocarboxylic Acid Metabolic Process Acetyl-CoA Metabolic Process Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Carboxylic Acid Metabolic Process Response To Electrical Stimulus Carbohydrate Metabolic Process Cellular Response To Glucocorticoid Stimulus Organic Acid Metabolic Process Cellular Response To Corticosteroid Stimulus Acyl-CoA Metabolic Process Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Oxidation-reduction Process Glycolytic Process Catabolic Process Coenzyme Biosynthetic Process Carbohydrate Catabolic Process Response To Glucocorticoid Response To Corticosteroid Cellular Response To Steroid Hormone Stimulus
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	bioinformatic desaturation diabesity discriminant dock1 elutriated ether fam126a gnptab goes granulocytes klf4 lipidome lipidomic monocyte mufa nfy pe peroxisomal phagocytic plasmalogen plasmalogens pls pufa rhm rnf96 silico squares transcriptomic
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	bioinformatic desaturation diabesity discriminant dock1 elutriated ether fam126a gnptab goes granulocytes klf4 lipidome lipidomic monocyte mufa nfy pe peroxisomal phagocytic plasmalogen plasmalogens pls pufa rhm rnf96 silico squares transcriptomic
Tagcloud (Intersection) ?