TRIM63 and SENP3

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		TRIM63	SENP3
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	SUMO1/sentrin/SMT3 specific peptidase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Nucleus Nucleolus Cytoplasm MLL1 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Proteolysis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			IgM levels ( 23118916)
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	13 interactors: ATF7IP CDK4 CDK6 EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21
Entrez ID		84676	26168
HPRD ID		05843	08339
Ensembl ID		ENSG00000158022	ENSG00000161956
Uniprot IDs		B4DN95 Q969Q1	Q9H4L4
PDB IDs		2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Positive Regulation Of Gene Expression Chromosome Organization Chromatin Organization Regulation Of Gene Expression Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Protein Catabolic Process Histone Deubiquitination Negative Regulation Of Cell Cycle Arrest Cellular Response To DNA Damage Stimulus Regulation Of Protein Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Signaling Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Cell Cycle Cell Communication Response To Steroid Hormone Response To Hormone Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Process Response To Organic Substance Cell Cycle Process Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Negative Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Cellular Response To Organic Substance Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Peptidyl-lysine Modification Proteasomal Protein Catabolic Process
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	adaptive allowing cathepsin conjugation cytochrome degraded deprivation desumoylation determinants drp1 extreme facilitates fate fission gtpase ischaemia modifier ogd perk prolongs protects recover reoxygenation rnai sumo sumoylation suppresses unfolded upr
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	adaptive allowing cathepsin conjugation cytochrome degraded deprivation desumoylation determinants drp1 extreme facilitates fate fission gtpase ischaemia modifier ogd perk prolongs protects recover reoxygenation rnai sumo sumoylation suppresses unfolded upr
Tagcloud (Intersection) ?