TRIM63 and MYBPC1

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		TRIM63	MYBPC1
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	myosin binding protein C, slow type
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Cytosol Myofibril Myosin Filament
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Titin Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Cell Adhesion Muscle Filament Sliding
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	10 interactors: CALM1 FHL1 FHL2 FHL3 MEOX2 NCF1 RAF1 TRIM55 TRIM63 TTN
Entrez ID		84676	4604
HPRD ID		05843	01185
Ensembl ID		ENSG00000158022	ENSG00000196091
Uniprot IDs		B4DN95 Q969Q1	A8KAB1 B3KPP3 Q00872 Q86TA8
PDB IDs		2D8U 3DDT	1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Muscle Structure Development Muscle Organ Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Organ Development Activation Of Adenylate Cyclase Activity Platelet Activation Muscle Contraction Positive Regulation Of Adenylate Cyclase Activity Muscle System Process Positive Regulation Of Lyase Activity Regulation Of Adenylate Cyclase Activity Striated Muscle Tissue Development Positive Regulation Of CAMP Biosynthetic Process Muscle Tissue Development Cardiovascular System Development Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Cardiac Muscle Cell Development System Development Platelet Degranulation Response To Hormone Death-inducing Signaling Complex Assembly Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Response To Abiotic Stimulus Regulation Of CAMP Metabolic Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Multicellular Organismal Development Cardiac Muscle Cell Differentiation Reactive Oxygen Species Metabolic Process Anatomical Structure Development Heart Development Response To Calcium Ion Skeletal Muscle Myosin Thick Filament Assembly Atrial Cardiac Muscle Cell Development Sarcomerogenesis Detection Of Muscle Stretch Cardiocyte Differentiation Regulation Of Body Fluid Levels Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Directional Locomotion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Wound Healing Anatomical Structure Morphogenesis Response To Glucocorticoid
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	ankrd2 annotation besides breed breeds dctn1 deg duroc est explaining giving grouped helpful libraries listed meat myl2 myogenesis neb novels piau pig postnatal prenatal prenatally tags transcriptome uncovering vertebrates
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	ankrd2 annotation besides breed breeds dctn1 deg duroc est explaining giving grouped helpful libraries listed meat myl2 myogenesis neb novels piau pig postnatal prenatal prenatally tags transcriptome uncovering vertebrates
Tagcloud (Intersection) ?