TRIM63 and USP7

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		TRIM63	USP7
Description		tripartite motif containing 63	ubiquitin specific peptidase 7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band Contractile Muscle Fiber	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body PML Body Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Titin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	P53 Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Innate Immune Response Negative Regulation Of Glycolytic Process Response To Glucocorticoid Response To Interleukin-1	Autophagosome Assembly DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Alkylation Repair Proteolysis DNA Damage Response Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Appendicular lean mass ( 33097823) Chronotype ( 30696823) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		331 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DMD DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16	349 interacting genes: ABCB1 ABRAXAS2 ACACB ACD ACLY ADAR ADARB1 AHNAK AKIRIN1 ALB ANKS1A ANXA1 ANXA9 ARHGEF17 ARMC5 ARNT2 ASPM ATXN1 AXIN1 BACH1 BCLAF1 BCOR BEND5 BRPF1 BSN CAMSAP1 CAV1 CBR1 CBX8 CCAR1 CCDC141 CCP110 CDC42BPA CDC5L CDR2L CENPE CEP250 CGNL1 CLSPN CLTC COBLL1 CREB3L3 CRY1 CSNK2A1 CTDP1 CTTN DAXX DBN1 DCD DCTPP1 DDX17 DDX21 DDX24 DDX3X DDX5 DDX50 DDX54 DDX60 DHX15 DHX30 DHX40 DHX9 DLST DMD DNAH5 DNAJA3 DNAJC16 DNHD1 DNMT3A DSP DST DUSP2 DYRK1A ECT2 EEA1 EEF1B2 EEF1D EEF1G EFCAB5 EFTUD2 ERCC6 ETS2 EWSR1 EXOSC10 FAM120C FAM186A FANCD2 FAT2 FAT3 FBXO38 FER1L6 FLG2 FMR1 FOXM1 FOXN2 FXR1 GATA1 GIGYF2 GMPS GNL3 GOLGB1 GON4L GRM1 GRWD1 GTF2I GTPBP4 H2AC20 H2BC26 H2BC3 H3C1 HECW1 HERC1 HERPUD1 HMOX1 HNRNPC HNRNPL HNRNPM HNRNPR HRNR HSPA9 HTRA2 IFNAR1 IGF2BP1 IGF2BP3 IGHG1 IKZF1 ILF3 IPCEF1 KDR KHDRBS1 KIAA1549L KIF13A KLF12 KLHL5 KLHL8 KMT2D KRI1 LAMA1 LEPR LIMA1 LINC02582 LINGO2 LPIN3 LRBA LTF LTV1 LUC7L3 MACF1 MAGEE1 MAL MARCHF7 MAST2 MATR3 MCMBP MDC1 MDM2 MDM4 MDN1 MEX3B MINK1 MLF2 MPRIP MTREX MYBBP1A MYC MYD88 MYH13 MYO1B MYO5A MYO7B NAT10 NEB NECAB2 NEDD4L NGEF NKRF NLRP11 NOM1 NOP2 NSD1 NUMA1 OGDH OTOF OTUD4 OVCH1 PABPC1 PARP1 PBRM1 PC PCARE PCGF2 PCLAF PDE3A PEG3 PELP1 PEPD PES1 PHLDB2 PICK1 PIP PKM PLA2G2A PLCH1 PLEC PLEKHO1 PLK1 PNN PNPLA4 POLI POP1 PPARG PPFIA1 PPIP5K1 PPL PPP1R12A PRDM16 PRPF19 PRPF40A PRPF8 PSIP1 PTEN PWP1 RAD18 RAD50 RADIL RAF1 RAI14 RALY RARA RB1 RBBP4 RBCK1 RBM15 RBM39 RCC2 RELA RFC1 RFFL RGPD8 RNF168 RNF220 RPL7A RPLP0 RPS3 RPS4X RPS6 RSL1D1 RSPH1 SALL1 SAMHD1 SAP130 SAP30BP SCML2 SDK2 SENP1 SERBP1 SF3B1 SF3B2 SF3B3 SHOC2 SIRT5 SLC15A1 SLC38A6 SLC4A5 SLIT2 SMAD3 SMARCA4 SMARCA5 SMARCC1 SMARCC2 SNCA SNRNP200 SNRNP70 SNX25 SOX9 SP4 SRPK1 SRRM2 SRSF4 STAU1 SUMO2 SUPT16H SYCP1 SYNE1 SYT14 SYVN1 TANK TBCB TERT TEX15 TFIP11 THOC2 THRAP3 TMPO TNPO3 TOP2A TOP2B TP53 TPM4 TPR TPX2 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO TSC22D2 TTN U2AF2 UBA52 UBAP2 UBC UBE2D3 UBE2E1 UBE2S UBN1 UBTF UHRF1 UMPS USP21 USP28 UTP14C UTY VARS1 VCP VIM VIRMA VPS13B VPS35 WWP2 XPC XRN2 YY1 ZC3HAV1 ZFR ZGRF1 ZMYM1 ZMYND8 ZNF335 ZNF423 ZNF76
Entrez ID		84676	7874
HPRD ID		05843	03950
Ensembl ID		ENSG00000158022	ENSG00000187555
Uniprot IDs		Q969Q1	B7Z855 B7ZAX6 Q6U8A4 Q93009
PDB IDs		2D8U 3DDT 4M3L	1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6M1K 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2 7VIJ 7XHH 7XHK 7XPY 8D4Z 9DEK 9DEL 9DEM 9DEN 9DEO 9DEP 9FIO 9FIP 9FIQ 9FIR 9FIS 9FIT 9FIU 9FIV 9IJU 9IML
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Protein Binding Sarcomere Organization Protein Modification By Small Protein Conjugation Protein Modification Process Structural Constituent Of Muscle Troponin Complex Nucleus Actomyosin Structure Organization Striated Muscle Contraction Z Disc Cardiac Muscle Contraction Ubiquitin Conjugating Enzyme Activity Protein K48-linked Deubiquitination Ubiquitin Protein Ligase Binding Contractile Muscle Fiber Sarcomere Protein Ubiquitination Troponin T Binding Protein Metabolic Process Myofibril Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Contraction Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Deubiquitinase Activity Proteolysis Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process TORC1 Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process TOR Signaling K48-linked Deubiquitinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Myofibril Assembly Nucleoplasm Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Cytosol Titin Binding	Nucleus RNA Binding Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process MRNA Processing MRNA Metabolic Process Chromatin Organization RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Cellular Response To Stress MRNA Binding Negative Regulation Of DNA-templated Transcription Response To Stress Negative Regulation Of RNA Biosynthetic Process DNA Damage Response DNA Metabolic Process Chromatin Remodeling Protein-containing Complex Spliceosomal Complex
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