UCHL5 and CAPZA1

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	CAPZA1
Gene Name		ubiquitin carboxyl-terminal hydrolase L5	capping protein (actin filament) muscle Z-line, alpha 1
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Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Ino80 Complex	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Vesicular Exosome WASH Complex
	Molecular Function	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding	Actin Binding Protein Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process	Protein Complex Assembly Movement Of Cell Or Subcellular Component Blood Coagulation Innate Immune Response Barbed-end Actin Filament Capping
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Factors involved in megakaryocyte development and platelet production Advanced glycosylation endproduct receptor signaling Innate Immune System
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)	Blood pressure ( 21572416)
Protein-Protein Interactions		96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1	7 interactors: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5
Entrez ID		51377	829
HPRD ID		10293	03347
Ensembl ID		ENSG00000116750	ENSG00000116489
Uniprot IDs		Q9Y5K5	P52907
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3	1MQ1 1MWN
Enriched GO Terms of Interacting Partners?		Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process	Midbrain Development Substantia Nigra Development 'de Novo' Posttranslational Protein Folding Central Nervous System Development 'de Novo' Protein Folding Neural Nucleus Development Cellular Response To Stimulus Nervous System Development Cell Projection Organization Locomotion Negative Regulation Of Fibril Organization Axonogenesis Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Neuron Projection Morphogenesis Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Fibril Organization Cell Morphogenesis Involved In Differentiation Regulation Of Cell Shape Signaling Brain Development Negative Regulation Of Skeletal Muscle Cell Differentiation Cell Communication Head Development Regulation Of Cellular Component Organization Neuron Projection Development Clathrin Coat Disassembly Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Production Enzyme Linked Receptor Protein Signaling Pathway Neuron Development System Development Cell Morphogenesis Protein Folding Anatomical Structure Morphogenesis Response To Methylmercury Neuron Differentiation Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Axon Guidance Anatomical Structure Development Regulation Of Skeletal Muscle Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Refolding
Tagcloud ?			cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6
Tagcloud (Difference) ?			cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6
Tagcloud (Intersection) ?