TRIM63 and OTUB1

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		TRIM63	OTUB1
Description		tripartite motif containing 63	OTU deubiquitinase, ubiquitin aldehyde binding 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band Contractile Muscle Fiber	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Titin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Inhibitor Activity
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Innate Immune Response Negative Regulation Of Glycolytic Process Response To Glucocorticoid Response To Interleukin-1	Adaptive Immune Response Immune System Process DNA Repair Proteolysis DNA Damage Response Protein Deubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Double-strand Break Repair
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Bipolar disorder ( 31043756)
Interacting Genes		331 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DMD DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16	59 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CCN6 CD274 CDKN1A CEBPA CPEB2 CSNK2A1 ECT2 ESR1 H2AX HSF1 IL1RL2 KDM1A LINC00857 MAPT MSH2 MYC NEDD8 OTUD6B PJA1 RFFL RHOA RNF126 RNF128 SETD7 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2S UBE2Z UBE4B USP15 USP21 USP28 YAP1
Entrez ID		84676	55611
HPRD ID		05843	08493
Ensembl ID		ENSG00000158022	ENSG00000167770
Uniprot IDs		Q969Q1	B3KUV5 Q96FW1
PDB IDs		2D8U 3DDT 4M3L	2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Protein Binding Sarcomere Organization Protein Modification By Small Protein Conjugation Protein Modification Process Structural Constituent Of Muscle Troponin Complex Nucleus Actomyosin Structure Organization Striated Muscle Contraction Z Disc Cardiac Muscle Contraction Ubiquitin Conjugating Enzyme Activity Protein K48-linked Deubiquitination Ubiquitin Protein Ligase Binding Contractile Muscle Fiber Sarcomere Protein Ubiquitination Troponin T Binding Protein Metabolic Process Myofibril Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Contraction Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Deubiquitinase Activity Proteolysis Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process TORC1 Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process TOR Signaling K48-linked Deubiquitinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Myofibril Assembly Nucleoplasm Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Cytosol Titin Binding	Post-translational Protein Modification Protein Modification Process Regulation Of Programmed Cell Death Protein Ubiquitination Regulation Of Apoptotic Process Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SMAD Binding Modification-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process In Utero Embryonic Development Negative Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Chordate Embryonic Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Proteolysis Involved In Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Stress Protein Polyubiquitination Proteolysis Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Gene Expression Regulation Of Developmental Process Ubiquitin Conjugating Enzyme Activity Response To Ionizing Radiation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?