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UCHL5 and RBCK1
Number of citations of the paper that reports this interaction (PMID
23105109
)
4
Data Source:
BioGRID
(two hybrid)
UCHL5
RBCK1
Gene Name
ubiquitin carboxyl-terminal hydrolase L5
RanBP-type and C3HC4-type zinc finger containing 1
Image
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
LUBAC Complex
Molecular Function
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Sequence-specific DNA Binding Transcription Factor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Binding
Biological Process
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Protein Polyubiquitination
Viral Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of NF-kappaB Import Into Nucleus
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Necroptotic Process
Protein Linear Polyubiquitination
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Cannabis dependence (
21668797
)
Protein-Protein Interactions
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
46 interactors:
APP
ARNT2
BACH1
CREBBP
IKBKG
IREB2
MKRN2
NAA10
NDUFAF3
NEDD4
NR1I2
OTUB2
OTUD6A
PAN2
PARK2
PCGF2
PRKCA
PSMD4
RNF181
RNF31
SOCS6
SYCE1
TNFAIP3
TRAF1
TRIM21
TRIM25
TRIM65
TRIML1
TSSK3
UBE2D3
UBE2D4
UBE2G1
UBE2K
UBE2L3
UBE2L6
UBE2N
UBE2S
UBE2U
UCHL5
UHRF2
USP15
USP2
USP21
USP32
USP49
USP7
Entrez ID
51377
10616
HPRD ID
10293
16643
Ensembl ID
ENSG00000116750
ENSG00000125826
Uniprot IDs
Q9Y5K5
A6PVK0
Q9BYM8
PDB IDs
3A7S
3IHR
3RII
3RIS
3TB3
2CRC
2LGY
4DBG
Enriched GO Terms of Interacting Partners
?
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Proteolysis
Proteasomal Protein Catabolic Process
Protein Metabolic Process
Protein Deubiquitination
Protein Modification By Small Protein Removal
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cellular Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Type I Interferon Production
Protein K63-linked Ubiquitination
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Response To Stress
Regulation Of Proteolysis
Histone Modification
Histone Deubiquitination
Cellular Response To Stress
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Protein K11-linked Ubiquitination
Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Innate Immune Response
Chromosome Organization
Protein K6-linked Ubiquitination
Protein K11-linked Deubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Nitrogen Compound Metabolic Process
Protein Monoubiquitination
Chromatin Modification
Protein Autoubiquitination
Negative Regulation Of Type I Interferon Production
Cellular Process
Regulation Of Transcription, DNA-templated
Tagcloud
?
1beta
ali
allocated
attenuates
autologous
c3hc4
dependently
dismutase
histology
intravenously
malondialdehyde
mda
oalt
occluded
orthotopic
oxidant
pathologic
peroxiredoxin
portal
prx
ranbp
restoring
sham
sod
started
u1
uh
ul
ulinastatin
Tagcloud (Difference)
?
1beta
ali
allocated
attenuates
autologous
c3hc4
dependently
dismutase
histology
intravenously
malondialdehyde
mda
oalt
occluded
orthotopic
oxidant
pathologic
peroxiredoxin
portal
prx
ranbp
restoring
sham
sod
started
u1
uh
ul
ulinastatin
Tagcloud (Intersection)
?