UCHL5 and DSC3

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	DSC3
Gene Name		ubiquitin carboxyl-terminal hydrolase L5	desmocollin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Ino80 Complex	Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Integral Component Of Membrane Desmosome
	Molecular Function	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding	Calcium Ion Binding Gamma-catenin Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)	Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1	5 interactors: CTNNB1 JUP PKP3 PKP4 UCHL5
Entrez ID		51377	1825
HPRD ID		10293	02604
Ensembl ID		ENSG00000116750	ENSG00000134762
Uniprot IDs		Q9Y5K5	Q14574
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process	Cell Junction Assembly Cell-cell Junction Organization Desmosome Assembly Cellular Response To Indole-3-methanol Desmosome Organization Cell-cell Junction Assembly Single Organismal Cell-cell Adhesion Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Adherens Junction Assembly Cell Adhesion Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cellular Component Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Protein Heterooligomerization Protein Localization To Plasma Membrane Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Cell-cell Adhesion Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Response To Mechanical Stimulus Skin Development Regulation Of Signal Transduction Plasma Membrane Organization Regulation Of Canonical Wnt Signaling Pathway Establishment Of Protein Localization To Membrane Central Nervous System Vasculogenesis Trachea Formation Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Regulation Of Signaling Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis
Tagcloud ?			cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?			cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Intersection) ?