UCHL5 and CFL1

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	CFL1
Description		ubiquitin C-terminal hydrolase L5	cofilin 1
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Filopodium Axon Growth Cone Cortical Actin Cytoskeleton Cell Leading Edge Lamellipodium Membrane Mitochondrial Membrane Vesicle Ruffle Membrane Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Cofilin-actin Rod Synaptic Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding	Actin Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Actin Filament Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Import Into Nucleus Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Actin Polymerization Or Depolymerization Response To Virus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Lamellipodium Assembly Response To Activity Hippocampus Development Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Cell Growth Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Synaptic Plasticity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Response To Amino Acid Host-mediated Activation Of Viral Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Cell Motility Modulation Of Chemical Synaptic Transmission Actin Filament Severing Establishment Of Spindle Localization Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Ether Cellular Response To Epidermal Growth Factor Stimulus Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Cell Leading Edge Negative Regulation Of Postsynaptic Density Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Dodecyldimethylamine N-oxide Copper Artenimol
Diseases
GWAS		Cannabis dependence ( 21668797)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	46 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CLCN5 ERBB2 ERBB3 ERBB4 ESR1 FLNA FNDC3B HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SNRPA SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		51377	1072
HPRD ID		10293	03261
Ensembl ID		ENSG00000116750	ENSG00000172757
Uniprot IDs		Q5LJA5 Q9Y5K5	P23528 V9HWI5
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP	1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO
Enriched GO Terms of Interacting Partners?		CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding	Actin Cytoskeleton Organization Actin Filament-based Process ATP Binding Regulation Of Organelle Organization Regulation Of Cellular Component Organization Nucleotide Binding Focal Adhesion Protein Modification Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Protein Kinase Activity Regulation Of Multicellular Organismal Process Actin Filament Cytoskeleton Positive Regulation Of Multicellular Organismal Process Mesenchyme Migration Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Regulation Of Membrane Potential Developmental Process Protein Phosphorylation Cell Junction Organization ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Actin Filament Organization Kinase Activity Protein-containing Complex Lamellipodium Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Phosphorylation Organelle Organization Positive Regulation Of Cell Activation Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Phosphatase Activity Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity
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