Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
UCHL5 and CASP14
Number of citations of the paper that reports this interaction (PMID
21800051
)
0
Data Source:
BioGRID
(pull down)
UCHL5
CASP14
Gene Name
ubiquitin carboxyl-terminal hydrolase L5
caspase 14, apoptosis-related cysteine peptidase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Nucleus
Cytoplasm
Keratin Filament
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Cysteine-type Endopeptidase Activity
Biological Process
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Proteolysis
Epidermis Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Keratinization
Cornification
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Cannabis dependence (
21668797
)
Protein-Protein Interactions
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
8 interactors:
CAPN1
CASP1
CASP10
CASP2
CASP4
CASP8
MEOX2
UCHL5
Entrez ID
51377
23581
HPRD ID
10293
05788
Ensembl ID
ENSG00000116750
ENSG00000105141
Uniprot IDs
Q9Y5K5
B2CIS9
P31944
PDB IDs
3A7S
3IHR
3RII
3RIS
3TB3
Enriched GO Terms of Interacting Partners
?
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Execution Phase Of Apoptosis
Proteolysis
Cell Death
Death
Cellular Response To Mechanical Stimulus
Regulation Of Endopeptidase Activity
Apoptotic Process
Regulation Of Peptidase Activity
Programmed Cell Death
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Proteolysis
Regulation Of Apoptotic Process
Response To Mechanical Stimulus
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Processing
Regulation Of Cell Death
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Apoptotic Signaling Pathway
Protein Metabolic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Signal Transduction
Extrinsic Apoptotic Signaling Pathway
Zymogen Activation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Mitochondrial Depolarization
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of Cell Death
Regulation Of Signal Transduction
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Interleukin-1 Alpha Secretion
Positive Regulation Of Peptidase Activity
Regulation Of Signaling
Luteolysis
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Interleukin-1 Alpha Production
Pyroptosis
Somite Specification
Intracellular Receptor Signaling Pathway
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Organic Substance
Response To Stress
Tagcloud
?
abc
bcl2af1
bcl2l10
biology
casp8
cd70
changed
cideb
cluster
correlate
fadd
hierarchical
hrk
igf1r
mcl1
needle
neoadjuvant
pathologic
profiling
prognosis
reflect
removed
substantially
therapeutically
tnfrsf25
tnfsf8
tunel
valuable
Tagcloud (Difference)
?
abc
bcl2af1
bcl2l10
biology
casp8
cd70
changed
cideb
cluster
correlate
fadd
hierarchical
hrk
igf1r
mcl1
needle
neoadjuvant
pathologic
profiling
prognosis
reflect
removed
substantially
therapeutically
tnfrsf25
tnfsf8
tunel
valuable
Tagcloud (Intersection)
?