TRIM63 and TNNT3

Number of citations of the paper that reports this interaction (PMID 15967462)
64

Data Source:
BioGRID (two hybrid)

		TRIM63	TNNT3
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	troponin T type 3 (skeletal, fast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Cytosol Troponin Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Actin Binding Tropomyosin Binding Troponin C Binding Calcium-dependent ATPase Activity Troponin I Binding Calcium-dependent Protein Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Skeletal Muscle Contraction Regulation Of Striated Muscle Contraction Metabolic Process Muscle Filament Sliding Regulation Of ATPase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	6 interactors: HAP1 NUDT3 SNUPN TNNI2 TRIM63 TSG101
Entrez ID		84676	7140
HPRD ID		05843	02822
Ensembl ID		ENSG00000158022	ENSG00000130595
Uniprot IDs		B4DN95 Q969Q1	P45378
PDB IDs		2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Diphosphoinositol Polyphosphate Catabolic Process SnRNA Import Into Nucleus Positive Regulation Of Neurotrophin Production Diadenosine Polyphosphate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly Catabolic Process RNA Import Into Nucleus Regulation Of Exocytosis Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Cellular Macromolecule Catabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Muscle Contraction Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle System Process Muscle Atrophy Viral Budding Hypothalamus Cell Differentiation Skeletal Muscle Adaptation Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Retrograde Axon Cargo Transport Viral Protein Processing Regulation Of Vesicle-mediated Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Protein Transport Positive Regulation Of Synaptic Transmission, GABAergic Cellular Response To Organic Cyclic Compound Establishment Of Protein Localization Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation Intracellular Transport Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Aromatic Compound Catabolic Process Regulation Of Beta-amyloid Formation Virion Assembly Regulation Of Cilium Assembly Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Positive Regulation Of ERBB Signaling Pathway
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	11p15 2g7 biallelic biallelically bipaternal boundary clustered contiguous escape frames h19 homologue igf2 imprinted imprinting kb kip2 l23mrp lacks lies outline polyadenylated rodent spliced synteny troponin ubiquitously wilms wts
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	11p15 2g7 biallelic biallelically bipaternal boundary clustered contiguous escape frames h19 homologue igf2 imprinted imprinting kb kip2 l23mrp lacks lies outline polyadenylated rodent spliced synteny troponin ubiquitously wilms wts
Tagcloud (Intersection) ?