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UCHL5 and PJA1
Number of citations of the paper that reports this interaction (PMID
22626734
)
2
Data Source:
BioGRID
(enzymatic study)
UCHL5
PJA1
Gene Name
ubiquitin carboxyl-terminal hydrolase L5
praja ring finger 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Cytoplasm
Molecular Function
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Cannabis dependence (
21668797
)
Protein-Protein Interactions
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
36 interactors:
ASCC2
ATP5C1
ATXN3
ATXN3L
EED
ESPL1
EZH2
GSR
HNRNPL
JOSD1
KIF22
MAGED1
MDM2
NDN
NDNL2
OTUB1
OTUB2
RIBC2
SPTBN1
STAM
STAMBP
SUZ12
UBC
UBE2D2
UBE2D3
UBE2L3
UBE2U
UCHL3
UCHL5
USP20
USP28
USP5
USP51
USP7
USP8
ZNF440
Entrez ID
51377
64219
HPRD ID
10293
02335
Ensembl ID
ENSG00000116750
ENSG00000181191
Uniprot IDs
Q9Y5K5
Q8NG27
PDB IDs
3A7S
3IHR
3RII
3RIS
3TB3
2L0B
Enriched GO Terms of Interacting Partners
?
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Protein Deubiquitination
Protein Modification By Small Protein Removal
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein K48-linked Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Regulation Of Protein Catabolic Process
Cellular Protein Metabolic Process
Catabolic Process
Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
DNA Repair
Cellular Response To Stress
Protein K63-linked Deubiquitination
Regulation Of Protein Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Metabolic Process
Regulation Of Proteolysis
Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Modification
Cell Cycle Process
Metabolic Process
Nitrogen Compound Metabolic Process
Protein Polyubiquitination
Regulation Of Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Chromosome Organization
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Protein Ubiquitination
Cell Cycle
Cytokinesis
Protein Modification By Small Protein Conjugation
Chromatin Modification
Cellular Response To Oxygen Levels
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Transcription, DNA-templated
Enzyme Linked Receptor Protein Signaling Pathway
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