TRIM63 and TNNI2

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		TRIM63	TNNI2
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	troponin I type 2 (skeletal, fast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Nucleus Cytosol Troponin Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Actin Binding Protein Binding Troponin T Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Skeletal Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding Positive Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Striated Muscle Contraction
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	13 interactors: ACTB CALM1 ESRRA HNF4G PKD2L1 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		84676	7136
HPRD ID		05843	01843
Ensembl ID		ENSG00000158022	ENSG00000130598
Uniprot IDs		B4DN95 Q969Q1	P48788
PDB IDs		2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Muscle Contraction Skeletal Muscle Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Muscle System Process Musculoskeletal Movement Actin-mediated Cell Contraction Regulation Of Muscle Contraction Actin Filament-based Movement Striated Muscle Contraction Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Steroid Hormone Mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Hormone-mediated Signaling Pathway Response To Lipid Cellular Response To Lipid Response To Organic Cyclic Compound Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Hormone Stimulus Regulation Of ATPase Activity DNA-templated Transcription, Initiation Actin Filament-based Process Neural Nucleus Development Organ Development Regulation Of Muscle Filament Sliding Speed Movement Of Cell Or Subcellular Component Regulation Of Striated Muscle Contraction Midbrain Development Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Muscle Filament Sliding Diaphragm Contraction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Signal Transduction Amacrine Cell Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction System Development Skeletal Muscle Atrophy Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glucocorticoid
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?