TRIM63 and ENO3

Number of citations of the paper that reports this interaction (PMID 18468620)
16

Data Source:
HPRD (two hybrid)

		TRIM63	ENO3
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	enolase 3 (beta, muscle)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Phosphopyruvate Hydratase Complex Extracellular Space Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Aging Pathogenesis Response To Drug Skeletal Muscle Tissue Regeneration Small Molecule Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	3 interactors: APP PNKD TRIM63
Entrez ID		84676	2027
HPRD ID		05843	11746
Ensembl ID		ENSG00000158022	ENSG00000108515
Uniprot IDs		B4DN95 Q969Q1	P13929
PDB IDs		2D8U 3DDT	2XSX
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Neuromuscular Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Skeletal Muscle Atrophy Axon Choice Point Recognition Striated Muscle Atrophy Muscle Atrophy Neuron Remodeling Skeletal Muscle Adaptation Neuromuscular Process Controlling Posture Regulation Of Synaptic Transmission, Dopaminergic Cellular Copper Ion Homeostasis Regulation Of Dopamine Metabolic Process Copper Ion Homeostasis Suckling Behavior Glutathione Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Peptide Biosynthetic Process Cellular Response To Dexamethasone Stimulus Mating Behavior Response To Dexamethasone Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Electrical Stimulus Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Axon Cargo Transport Mating Neuromuscular Junction Development Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Neurological System Process Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	64306537h0rik coiled disorganized eno1 eno2 eno4 enolase epididymal flagellum fs gal galactosidase glycolysis glycolytic gm5506 gt infertile isozymes pan piece renamed sheath sperm spermatogenic testes testis transcribed uncharacterized utilize
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	64306537h0rik coiled disorganized eno1 eno2 eno4 enolase epididymal flagellum fs gal galactosidase glycolysis glycolytic gm5506 gt infertile isozymes pan piece renamed sheath sperm spermatogenic testes testis transcribed uncharacterized utilize
Tagcloud (Intersection) ?