UCHL5 and FLG

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	FLG
Gene Name		ubiquitin carboxyl-terminal hydrolase L5	filaggrin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Ino80 Complex	Nucleus Intermediate Filament Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process	Multicellular Organismal Development Keratinocyte Differentiation Establishment Of Skin Barrier
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)	Atopic dermatitis ( 21666691) Eating disorders ( 23568457)
Protein-Protein Interactions		96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1	3 interactors: CSNK2A1 PCSK6 UCHL5
Entrez ID		51377	2312
HPRD ID		10293	15920
Ensembl ID		ENSG00000116750	ENSG00000143631
Uniprot IDs		Q9Y5K5	P20930
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process	Regulation Of Proteasomal Protein Catabolic Process Nerve Growth Factor Production Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Morphogenesis Lateral Ventricle Development Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Peptide Hormone Processing Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Brain Morphogenesis Ventricular System Development Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Embryonic Axis Specification Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Multicellular Organismal Development Negative Regulation Of Proteasomal Protein Catabolic Process Anterior/posterior Axis Specification Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of BMP Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Midbrain Development
Tagcloud ?			activating adaptor associates autocrine becomes constitutive exchange expected fgf fgfr fibroblast gamma grb2 guanine instead neither nucleotide p90 phospholipase phosphorylated plc ras shc sos src suramin transformed tyrosine v
Tagcloud (Difference) ?			activating adaptor associates autocrine becomes constitutive exchange expected fgf fgfr fibroblast gamma grb2 guanine instead neither nucleotide p90 phospholipase phosphorylated plc ras shc sos src suramin transformed tyrosine v
Tagcloud (Intersection) ?